Marie-Therese Winkler

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The dopamine transporter (DAT) is a crucial regulator of dopaminergic neurotransmission, controlling the length and brevity of dopaminergic signaling. DAT is also the primary target of psychostimulant drugs such as cocaine and amphetamines. Conversely, methylphenidate and amphetamine are both used clinically in the treatment of attention-deficit(More)
The dopamine transporter (DAT) is responsible for sequestration of extracellular dopamine (DA). The psychostimulant amphetamine (AMPH) is a DAT substrate, which is actively transported into the nerve terminal, eliciting vesicular depletion and reversal of DA transport via DAT. Here, we investigate the role of the DAT C terminus in AMPH-evoked DA efflux(More)
Background Neuronal functions, such as excitability or endo-and exo-cytosis, require phosphatidylinositol-4,5-bisphosphate (PIP 2) since ion channels and other proteins involved in these processes are regulated by PIP 2. Monoamine transporters control neurotransmission by removing monoa-mines from the extracellular space. They also display channel(More)
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