Marie Sankaran

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A retrospective study of 139 glioma patients was conducted in an effort to audit management. Factors affecting survival were studied using a Cox Proportional Hazard Model. These factors included age, sex, location, grade, type of surgery, use of radiotherapy, presenting symptoms, Karnofsky score on admission and Karnofsky score 3 months following surgery.(More)
Twenty-five human placentas were studied for suitability in a microvascular exercise. The size and useful length of vessels were measured, and different microvascular anastomoses were performed. The size of the placenta vessels compared well with reported sizes of intracranial arteries. We suggest the use of placenta by neurosurgeons as complementary to(More)
INTRODUCTION The influences of chronic administration of low and high doses of melatonin on the characteristics of circadian rhythms of glucose, reduced glutathione, total protein were studied, in order to investigate whether melatonin could modulate these rhythms differently. METHODS Pharmacological doses of melatonin (0.5 mg/kg and 1.0mg/kg body weight)(More)
BACKGROUND Peak serum concentrations of methotrexate (MTX) have been reported to correlate with outcome in osteosarcoma (OS). Modification of the MTX dose to achieve peak levels between 700 and 1,000 micromol/L has been recommended. The goal of the study was to assess whether there is a correlation between histologic necrosis of the tumor and/or prognosis(More)
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