Marie-Pierre Puisségur

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BACKGROUND Epithelial-mesenchymal interactions are critical in regulating many aspects of vertebrate embryo development, and for the maintenance of homeostatic equilibrium in adult tissues. The interactions between epithelium and mesenchyme are believed to be mediated by paracrine signals such as cytokines and extracellular matrix components secreted from(More)
Specificity of interaction between a microRNA (miRNA) and its targets crucially depends on the seed region located in its 5'-end. It is often implicitly considered that two miRNAs sharing the same biological activity should display similarity beyond the strict six nucleotide region that forms the seed, in order to form specific complexes with the same mRNA(More)
Human melanoma cells express various tumour antigens that are recognized by CD8(+) cytotoxic T lymphocytes (CTLs) and elicit tumour-specific responses in vivo. However, natural and therapeutically enhanced CTL responses in melanoma patients are of limited efficacy. The mechanisms underlying CTL effector phase failure when facing melanomas are still largely(More)
Tuberculin-skin-test (TST) is widely used for the diagnosis of Tuberculosis. Negative TSTs are occasionally found in individuals vaccinated or infected by Mycobacterium tuberculosis. We show that false negative results are due to a lack of the Tuberculin-specific immune response as replacing tuberculin by unselected M. tuberculosis antigens improved the(More)
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