Marie Persson

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In this paper we analyse the operating room planning at a department of orthopaedic surgery in Sweden. We focus on the problem of meeting the uncertainty in demand of patient arrival and surgery duration and at the same time maximizing the utilization of operating room (OR) time. With a discrete-event model we simulate how different management polices(More)
This paper provides a survey and analysis of applications of Agent Based Simulation (ABS). A framework for describing and assessing the applications is presented and systematically applied. A general conclusion from the study is that even if ABS seems a promising approach to many problems involving simulation of complex systems of interacting entities, it(More)
There is a growing proportion of elderly which increases the demand for health care. As a consequence health care costs are rising and the need for hospital resource planning seems urgent. Different aspects (often conflicting) such as patient demand, clinical need and political ambitions must be considered. In this paper we propose a model for analyzing(More)
Idiopathic dilated cardiomyopathy is a severe disease of unknown etiology. Accumulating evidence suggests that agonist-like autoantibodies against the β1 adrenoceptor in the circulation of dilated cardiomyopathy may play an important role. The aim of this study was to evaluate the effects of the selective β1-adrenoceptor blocker, bisoprolol, on(More)
Type 2 T-helper cell (Th2)-skewed immunity is associated with successful pregnancy and the ability to easily direct immune responses to a Th2-polarised profile may be an evolutionary benefit. The Th2-like immunity associated with allergic disease might generate favourable effects for the maintenance of pregnancy, but could also promote development of(More)
INTRODUCTION Allergic women have been reported to give birth to more children than non-allergic women, speculatively explained by the former's predisposition for Th2 polarization, possibly favoring pregnancy. AIM The aim of this study was to test the hypothesis that allergy is associated with more Th2-deviated responses to paternal antigens throughout(More)
Normal pregnancy and allergy are both characterized by a T helper (Th) 2 deviation. In the current study, we hypothesized that paternal antigen-induced cytokine responses during pregnancy would be deviated toward Th2 and an anti-inflammatory profile, and that the Th2 deviation would be more pronounced in allergic pregnant women. Blood samples were collected(More)
We aimed to prospectively investigate the paternal antigen-induced cytokine secretion by peripheral blood mononuclear cells (PBMCs) in response to hormone treatment in women undergoing in vitro fertilisation (IVF) and to examine the predictive value of the cytokine secretion profile in the outcome of IVF treatment, in a pilot study. Twenty-five women were(More)