Marie Persson

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This paper provides a survey and analysis of applications of Agent Based Simulation (ABS). A framework for describing and assessing the applications is presented and systematically applied. A general conclusion from the study is that even if ABS seems a promising approach to many problems involving simulation of complex systems of interacting entities, it(More)
BACKGROUND New pharmacological therapies are challenging the healthcare systems, and there is an increasing need to assess their therapeutic value in relation to existing alternatives as well as their potential budget impact. Consequently, new models to introduce drugs in healthcare are urgently needed. In the metropolitan health region of Stockholm,(More)
INTRODUCTION Allergic women have been reported to give birth to more children than non-allergic women, speculatively explained by the former's predisposition for Th2 polarization, possibly favoring pregnancy. AIM The aim of this study was to test the hypothesis that allergy is associated with more Th2-deviated responses to paternal antigens throughout(More)
BACKGROUND Generic atypical antipsychotic drugs offer health authorities opportunities for considerable savings. However, schizophrenia and bipolar disorders are complex diseases that require tailored treatments. Consequently, generally there have been limited demand-side measures by health authorities to encourage the preferential prescribing of generics.(More)
Normal pregnancy and allergy are both characterized by a T helper (Th) 2 deviation. In the current study, we hypothesized that paternal antigen-induced cytokine responses during pregnancy would be deviated toward Th2 and an anti-inflammatory profile, and that the Th2 deviation would be more pronounced in allergic pregnant women. Blood samples were collected(More)
Along with continuously increasing computerization, our expectations on software and hardware reliability increase considerably. Therefore, software reliability has become one of the most important software quality attributes. Software reliability modeling based on test data is done to estimate whether the current reliability level meets the requirements(More)
The article presents a new algorithm for handling concept drift: the Trigger-based Ensemble (TBE) is designed to handle concept drift in surgery prediction but it is shown to perform well for other classification problems as well. At the primary care, queries about the need for surgical treatment are referred to a surgeon specialist. At the secondary care,(More)