Isabelle Amado22
Marie-Chantal Bourdel22
Jean-Pierre Olié21
Bruno Millet10
Gwenaëlle Le Pen10
22Isabelle Amado
22Marie-Chantal Bourdel
21Jean-Pierre Olié
10Bruno Millet
10Gwenaëlle Le Pen
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  • Simon L Girard, Julie Gauthier, Anne Noreau, Lan Xiong, Sirui Zhou, Loubna Jouan +16 others
  • 2011
Schizophrenia is a severe psychiatric disorder that profoundly affects cognitive, behavioral and emotional processes. The wide spectrum of symptoms and clinical variability in schizophrenia suggest a complex genetic etiology, which is consistent with the numerous loci thus far identified by linkage, copy number variation and association studies. Although(More)
  • Julie Gauthier, Tabrez J Siddiqui, Peng Huashan, Daisaku Yokomaku, Fadi F Hamdan, Nathalie Champagne +15 others
  • 2011
Growing genetic evidence is converging in favor of common pathogenic mechanisms for autism spectrum disorders (ASD), intellectual disability (ID or mental retardation) and schizophrenia (SCZ), three neurodevelopmental disorders affecting cognition and behavior. Copy number variations and deleterious mutations in synaptic organizing proteins including NRXN1(More)
Heterozygous mutations in FOXP2, which encodes a forkhead transcription factor, have been shown to cause developmental verbal dyspraxia and language impairment. FOXP2 and its closest homolog, FOXP1, are coexpressed in brain regions that are important for language and cooperatively regulate developmental processes, raising the possibility that FOXP1 may also(More)
  • Florence Le Jeune, Marc Vérin, Karim N'Diaye, Dominique Drapier, Emmanuelle Leray, Sophie Tezenas Du Montcel +16 others
  • 2010
BACKGROUND High-frequency bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) is a promising treatment in refractory obsessive-compulsive disorder (OCD). METHOD Using the crossover, randomized, and double-blind procedure adopted by the STOC study, 10 patients treated with high-frequency bilateral STN DBS underwent am 18-fluorodeoxyglucose(More)
Several lines of evidence suggest that obsessive compulsive disorder (OCD) could be the consequence of glutamatergic dysfunction. We performed a case-control study in 156 patients and 141 controls and the transmission disequilibrium test in 124 parent-offspring trios to search for association between OCD and two kainate receptors, GRIK2 and GRIK3. Using(More)
  • David Gourion, Céline Goldberger, Marie-Chantal Bourdel, Frank Jean Bayle, Bruno Millet, Jean-Pierre Olie +1 other
  • 2003
Markers of vulnerability have been identified in schizophrenia, and among them, neurological soft-signs (NSS) and minor physical anomalies (MPAs) also seem to occur in biological relatives. The similarities of these developmental markers within families may depend on either genetic or non-genetic factors. The aim of the study was to investigate the(More)
Smoking cues (SCs) refer to smoking-associated environmental stimuli that may trigger craving and withdrawal symptoms, and predispose to relapse in smokers. Although previous brain imaging studies have explored neural responses to SCs, no study has characterized the effects of SCs on cerebral activity in smokers engaged in an attention-demanding cognitive(More)
  • Pierre Burbaud, Anne-Hélène Clair, Nicolas Langbour, Sara Fernandez-Vidal, Michel Goillandeau, Thomas Michelet +20 others
  • 2013
Doubt, and its behavioural correlate, checking, is a normal phenomenon of human cognition that is dramatically exacerbated in obsessive-compulsive disorder. We recently showed that deep brain stimulation in the associative-limbic area of the subthalamic nucleus, a central core of the basal ganglia, improved obsessive-compulsive disorder. To understand the(More)
  • Emilie Magaud, Oussama Kebir, Anne Gut, Dominique Willard, François Chauchot, Jean-Pierre Olie +2 others
  • 2010
Some of the cognitive impairments of schizophrenia are already detectable before the onset of the disease, and could help to identify individuals at higher risk of psychosis. In patients with schizophrenia, semantic verbal fluency (VF) is more impaired than phonological fluency. We investigated whether the same profile is present in young patients at Ultra(More)
The exposure to methylazoxymethanol (MAM) at embryonic day 17 (E17) results in behavioral anomalies in male rats that mimic several features of schizophrenia, including their emergence after puberty. Given that both men and women are likely to develop this illness and that currently no animal model is validated for females, we examined the behavioral(More)