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DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities.

• Atsushi Shibata, Davide Moiani, +16 authors John A. Tainer
• Molecular cell
• 2014

MRE11 within the MRE11-RAD50-NBS1 (MRN) complex acts in DNA double-strand break repair (DSBR), detection, and signaling; yet, how its endo- and exonuclease activities regulate DSBR by nonhomologous… (More)

Lactococcal phage p2 ORF35-Sak3 is an ATPase involved in DNA recombination and AbiK mechanism.

• Erika Scaltriti, Hélène Launay, +9 authors J Masson
• Molecular microbiology
• 2011

Virulent phages of the Siphoviridae family are responsible for milk fermentation failures worldwide. Here, we report the characterization of the product of the early expressed gene orf35 from… (More)

The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice

• Ismail Hassan Ismail, Jean-Philippe Gagné, +6 authors Michael J. Hendzel
• Nature Cell Biology
• 2015

DNA double-strand breaks (DSBs) are repaired mainly by non-homologous end joining or homologous recombination (HR). Cell cycle stage and DNA end resection are believed to regulate the commitment to… (More)

Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum

• Marie-Michelle Genois, Angana Mukherjee, +7 authors J Masson
• Nucleic acids research
• 2012

In most organisms, the primary function of homologous recombination (HR) is to allow genome protection by the faithful repair of DNA double-strand breaks. The vital step of HR is the search for… (More)

Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum

• Marie-Michelle Genois, Marie Plourde, +4 authors J Masson
• Nucleic acids research
• 2015

To achieve drug resistance Leishmania parasite alters gene copy number by using its repeated sequences widely distributed through the genome. Even though homologous recombination (HR) is ascribed to… (More)

Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE 11 Nuclease Activities

• Shibata, Davide, +10 authors Robert G
• 2017

PDB ID : 4O24 Title : DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities Authors : Shibata, A.; Moiani, D.; Arvai, A.S.; Perry, J.; Harding, S.M.; Genois,… (More)

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