Marie-Luise Bouvier

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OBJECTIVES Although schizophrenia affects both human genders, there are gender-dependent differences with respect to age of onset, clinical characteristics, course and prognosis of the disease. METHODS To investigate sex-dependent differences in motor coordination and activity as well as in cognitive and social behavior, we repeatedly tested female (n =(More)
INTRODUCTION An increased risk for metabolic syndrome has been described for patients with psychotic disorders. Antipsychotic drugs possibly contribute to metabolic changes. METHODS Haloperidol or clozapine was orally fed to male and female Sprague Dawley rats for 12 weeks, and body weight gain, food and water intake were measured. The serum levels of(More)
In an attempt to model neurodevelopmental defects that may contribute to the outbreak of schizophrenia after adolescence, the present study examined the effects of prenatal interventions in rats, including injections of kainic acid, on motor, cognitive and social behaviour, which was assessed repeatedly between PDs 56-62 (week 8) and 168-174 (week 24), as(More)
OBJECTIVES The aim of our study was to investigate the impact of typical and atypical antipsychotic drugs on leptin concentration in blood and changes in the receptor expression in the hypothalamus of male Wistar rats. METHODS From the age of 13 to 18 weeks, three groups of 20 animals were fed an average dose of 3.5 + 0.03 mg/ kg body weight (BW)(More)
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