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Structure and Functional Analysis of the RNA- and Viral Phosphoprotein-Binding Domain of Respiratory Syncytial Virus M2-1 Protein
Respiratory syncytial virus (RSV) protein M2-1 functions as an essential transcriptional cofactor of the viral RNA-dependent RNA polymerase (RdRp) complex by increasing polymerase processivity. M2-1Expand
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Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation
Significance Human respiratory syncytial virus (HRSV) is the leading cause of lower respiratory tract illness in young children; however, no vaccine exists and current immunoprophylaxis regimes areExpand
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HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages
Significance Human immunodeficiency viruses (HIV) have developed strategies to interfere with DNA repair in host cells. Some DNA repair pathways represent restriction mechanisms that counteract theExpand
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The Insertion of Fluorescent Proteins in a Variable Region of Respiratory Syncytial Virus L Polymerase Results in Fluorescent and Functional Enzymes But with Reduced Activities
The respiratory syncytial virus (RSV) Large protein L is the catalytic subunit of the RNA-dependent RNA polymerase complex. Currently, no structural information is available for RSV L. SequenceExpand
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Human Herpesvirus 8 Genotype E in Patients with Kaposi Sarcoma, Peru
To determine human herpesvirus 8 (HHV-8) K1 genotypes in patients with Kaposi sarcoma (KS) from Peru, we characterized HHV-8 in 25 KS biopsy samples. Our findings of 8 A, 1 B, 14 C, and 2 E subtypesExpand
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Intracellular transport and egress of hepatitis B virus.
Hepatitis B virus (HBV) replicates its genomic information in the nucleus via transcription and therefore has to deliver its partially double stranded DNA genome into the nucleus. Like other virusesExpand
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1H, 13C, and 15N resonance assignment of the central domain of hRSV transcription antitermination factor M2-1
M2-1 is an essential co-factor of the respiratory syncytial virus, an important respiratory pathogen in infants and calves. It acts as a transcription antitermination factor which enhances theExpand
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How SLX4 cuts through the mystery of HIV-1 Vpr-mediated cell cycle arrest
Vpr is one of the most enigmatic viral auxiliary proteins of HIV. During the past twenty years, several activities have been ascribed to this viral protein, but one, its ability to mediate cell cycleExpand
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The chaperone dynein LL1 mediates cytoplasmic transport of empty and mature hepatitis B virus capsids.
BACKGROUND & AIMS Hepatitis B virus (HBV) has a DNA genome but replicates within the nucleus by reverse transcription of an RNA pregenome, which is converted to DNA in cytoplasmic capsids. Capsids inExpand
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