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Empowered by the recent advances in next generation sequencing and bioinformatics technology, an unprecedented wave of integrated transcriptomic and genomic studies have impacted the field of bladder… Continue Reading
Our group and others have previously demonstrated the presence of TERT promoter mutations (TERT-mut) in 60–80% of urothelial carcinomas and some of their histologic variants. Five other genes have… Continue Reading
Methylation of cytosine residues exerts a critical role in silencing gene transcription. Importantly, DNA methylation patterns are often altered in cancer, with many tumors showing site-specific gain… Continue Reading
In the present study, we generated and characterized a splice site-specific monoclonal antibody that selectively detects the calcineurin-binding dynamin1 splice variant dynamin1xb. Calcineurin is a… Continue Reading
Abstract Recent advances in sequencing technologies, proteomics, and metabolomics have led to the identification of numerous molecular alterations across solid tumors including prostate cancer. The… Continue Reading