Marie-Laure Bonnet

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Tyrosine kinase inhibitors (TKIs) have profoundly changed the natural history of chronic myeloid leukemia (CML). However, acquired resistance to imatinib, dasatinib or nilotinib (1(st) and 2(nd) generation TKIs), due in part to BCR-ABL1 kinase mutations, has been largely described. These drugs are ineffective on the T315I gatekeeper substitution, which(More)
A new selected-configuration interaction method is proposed, based on the use of local orbitals. A corresponding code has been written, which is devoted to CI calculations of rather large systems (about 50-100 carbon-like atoms). Taking advantage of the locality, and then of the fact that interactions vanish when the distance is large, the dimension of the(More)
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