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Hox genes regulate digit patterning by controlling the wavelength of a Turing-type mechanism.

• Rushikesh Sheth, Luciano Marcon, +6 authors Maria A Ros
• Science
• 2012

The formation of repetitive structures (such as stripes) in nature is often consistent with a reaction-diffusion mechanism, or Turing model, of self-organizing systems. We used mouse genetics to… (More)

Organizing axes in time and space; 25 years of colinear tinkering.

• Marie Kmita, Denis Duboule
• Science
• 2003

During vertebrate development, clustered genes from the Hox family of transcription factors are activated in a precise temporal and spatial sequence that follows their chromosomal order (the "Hox… (More)

A dual role for Hox genes in limb anterior-posterior asymmetry.

• József Zákány, Marie Kmita, Denis Duboule
• Science
• 2004

Anterior-to-posterior patterning, the process whereby our digits are differently shaped, is a key aspect of limb development. It depends on the localized expression in posterior limb bud of Sonic… (More)

Serial deletions and duplications suggest a mechanism for the collinearity of Hoxd genes in limbs.

• Marie Kmita, Nadine Fraudeau, Yann Hérault, Denis Duboule
• Nature
• 2002

Hox genes, located at one end of the HoxD cluster, are essential for the development of the extremities of our limbs; that is, the digits. This 'collinear' correspondence is accompanied by a gradual… (More)

Regulatory constraints in the evolution of the tetrapod limb anterior-posterior polarity.

• Basile Tarchini, Denis Duboule, Marie Kmita
• Nature
• 2006

The anterior to posterior (A-P) polarity of the tetrapod limb is determined by the confined expression of Sonic hedgehog (Shh) at the posterior margin of developing early limb buds, under the control… (More)

Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function.

• Marie Kmita, Basile Tarchini, József Zákány, Malcolm Logan, Clifford J Tabin, Denis Duboule
• Nature
• 2005

Vertebrate HoxA and HoxD cluster genes are required for proper limb development. However, early lethality, compensation and redundancy have made a full assessment of their function difficult. Here we… (More)

GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis.

• Javier López-Ríos, Dario Speziale, +7 authors Rolf Zeller
• Developmental cell
• 2012

Inactivation of Gli3, a key component of Hedgehog signaling in vertebrates, results in formation of additional digits (polydactyly) during limb bud development. The analysis of mouse embryos… (More)

Localized and Transient Transcription of Hox Genes Suggests a Link between Patterning and the Segmentation Clock

• József Zákány, Marie Kmita, Pilar Alarcón, José-Luis de la Pompa, Denis Duboule
• Cell
• 2001

During development, Hox gene transcription is activated in presomitic mesoderm with a time sequence that follows the order of the genes along the chromosome. Here, we show that Hoxd1 and other Hox… (More)

Mechanisms of Hox gene colinearity: transposition of the anterior Hoxb1 gene into the posterior HoxD complex.

• Marie Kmita, Frank van der Hoeven, József Zákány, Robb K Krumlauf, Denis Duboule
• Genes & development
• 2000

Transposition of Hoxd genes to a more posterior (5') location within the HoxD complex suggested that colinearity in the expression of these genes was due, in part, to the existence of a silencing… (More)

Evolutionary conserved sequences are required for the insulation of the vertebrate Hoxd complex in neural cells.

• Marie Kmita, Basile Tarchini, Denis Duboule, Yann Hérault
• Development
• 2002

Transcriptional regulation of vertebrate Hox genes involves enhancer sequences located either inside or outside the gene clusters. In the mouse Hoxd complex, for example, series of contiguous genes… (More)

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