Marie Helene Leblanc

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BACKGROUND Because patients with chronic heart failure (CHF) can benefit from specific treatment for coexisting obstructive and central sleep apnea (CSA), there is a need to develop accurate screening tools to identify or exclude these sleep-related breathing disturbances (SRBDs) in patients with CHF. OBJECTIVES To evaluate, prospectively, the diagnostic(More)
BACKGROUND AND PURPOSE Giving glucose before hypoxic ischemia worsens brain injury in piglets. Does giving glucose after hypoxic ischemia affect severity of injury? METHODS Forty-three 0- to 3-day-old pigs were used. All piglets received 2 U/kg insulin before injury to prevent stress-induced hyperglycemia. Hypoxic ischemic brain damage was induced by(More)
BACKGROUND AND PURPOSE The administration of glucose has been shown to worsen brain injury in adult animals but has no effect on the severity of injury in newborn rats. We wished to see whether the results in newborn rats could be extended to another newborn animal. METHODS In 44 0- to 3-day-old piglets, hypoxic-ischemic central nervous system damage was(More)
This prospective study was designed to identify the role of postnatal penicillin prophylaxis in the prevention of neonatal group B streptococcus (GBS) infection. We studied 10 998 infants. Of these, 5389 were in the penicillin prophylaxis group (PP) and 5609 infants did not receive penicillin prophylaxis (NPP). Infants were allocated to treatment by month(More)
Hypoxic ischemic injury to the brain was induced in 12 0- to 3-day-old piglets. At time 0, the carotid arteries were ligated, and the blood pressure was reduced by one third by hemorrhage. At 15 min, inspired FIO2 was reduced from 50 to 6%. After 10 min of flat EEG, the FIO2 was changes to 100%, the carotid ligations were released, and the withdrawn blood(More)
Keeping babies warm whether using incubator or radiant warmers is important in optimizing their chances of survival. Many design changes have occurred in devices for keeping babies warm, while few controlled studies using clinically important end points have been conducted to assess these changes. Radiant warmers produce larger evaporative heat and water(More)
Although much additional work is needed to accurately define the physics of thermal transfer between a baby and the environment, especially with respect to convection and evaporation, it is currently possible to calculate estimates of the quantities in many conditions. These estimates are valuable in predicting the effect various design changes will have on(More)
BACKGROUND AND METHODS We demonstrated earlier in our laboratories that fructose-1,6-bisphosphate (FDP) would improve the outcome of hypoxic ischemic injury to the brain in the adult rabbit. Since many human newborns suffer hypoxic injury to the brain, with a secondary ischemic component due to hypoxic cardiac failure, we set out to reproduce similar(More)
Previous studies have demonstrated that an acute intravenous administration of nitro-L-arginine methyl ester (L-NAME) causes a sustained hypertension and widespread vasoconstriction. However, little information is available regarding the chronic effect of L-NAME on circulatory hemodynamics. Therefore, the purpose of the present study was to characterize(More)
BACKGROUND AND PURPOSE The excitatory amino acid inhibitor MK-801 has been shown in many animals species to protect against hypoxic-ischemic brain injury. We sought to determine whether hypoxic-ischemic injury to the newborn pig's brain could be prevented by the use of MK-801. METHODS Hypoxic-ischemic injury to the brain was induced in forty 0-3-day-old(More)