Marie-Françoise Chrétien

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Mitochondria play a primary role in cellular energetic metabolism, homeostasis, and death. They possess their own multicopy genome, which is maternally transmitted. Mitochondria are directly involved at several levels in the reproductive process since their functional status influences the quality of oocytes and contributes to the process of fertilization(More)
BACKGROUND Recent work has shown that mitochondrial biogenesis and mitochondrial functions are critical determinants of embryonic development. However, the expression of the factors controlling mitochondrial biogenesis in early embryogenesis has received little attention so far. METHODS We used real-time quantitative PCR to quantify mitochondrial DNA(More)
Mitochondria play a primary role in cellular energetic metabolism. They possess their own DNA, which is exclusively maternally transmitted. The relatively recent idea that mitochondria may be directly involved in human reproduction is arousing increasing interest in the scientific and medical community. It has been shown that the functional status of(More)
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