Marie Escande

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Maintenance of cell survival is essential for proper embryonic development. In the mouse, Notchless homolog 1 (Drosophila) (Nle1) is instrumental for survival of cells of the inner cell mass upon implantation. Here, we analyze the function of Nle1 after implantation using the Meox2(tm1(cre)Sor) mouse that expresses the Cre recombinase specifically in the(More)
France Notchless (Nle) has been identified in Drosophila as a direct regulator of Notch activity. In the mouse, we have previously demonstrated that mNle is instrumental for the maintenance of pluripotent cells at the blastocyst stage. To characterize the function of mNle in post-implantation embryos, we used mosaic epi-blast-specific inactivation of a(More)
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