Marie Engelene J. Obien

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Microelectrode arrays and microprobes have been widely utilized to measure neuronal activity, both in vitro and in vivo. The key advantage is the capability to record and stimulate neurons at multiple sites simultaneously. However, unlike the single-cell or single-channel resolution of intracellular recording, microelectrodes detect signals from all(More)
In this paper, we first introduce extended de Bruijn graphs to design extended shift registers that are functionally equivalent but not structurally equivalent to shift registers. Using the extended shift registers, we present a new secure and testable scan design approach that aims to satisfy both testability and security of digital circuits. The approach(More)
We present a CMOS-based high-density microelectrode array (HD-MEA) system that enables high-density mapping of brain slices in-vitro with multiple readout modalities. The 4.48×2.43 mm2 array consists of 59,760 micro-electrodes at 13.5 µm pitch (5487 electrodes/mm2). The overall system features 2048 action-potential, 32 local-field-potential and 32 current(More)
High-density microelectrode arrays (HDMEAs) provide the capability to monitor the extracellular electric potential of multiple neurons at subcellular resolution over extended periods of time. In contrast, patch clamp allows for intracellular, sub-threshold recordings from a single patched neuron for very limited time on the order of an hour. Therefore, it(More)
Today's digital circuits demand both high speed performance and miniaturization of chip size. As a result, delay fault testing has become very important to verify the quality requirements of VLSI chips. Full scan has been used to generate test patterns that achieves high fault coverage, of which the standard techniques for delay scan testing are skewed-load(More)
Due to the difficulty of test pattern generation for sequential circuits, several design-for-testability (DFT) approaches have been proposed. An improvement to these current approaches is needed to cater to the requirements of today’s more complicated chips. This paper introduces a new DFT method applicable to high-level description of circuits, which(More)
A novel system to cultivate and record from organotypic brain slices directly on high-density microelectrode arrays (HD-MEA) was developed. This system allows for continuous recording of electrical activity of specific individual neurons at high spatial resolution while monitoring at the same time, neuronal network activity. For the first time, the(More)