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Inflammation is a complex, multi-scale biologic response to stress that is also required for repair and regeneration after injury. Despite the repository of detailed data about the cellular and molecular processes involved in inflammation, including some understanding of its pathophysiology, little progress has been made in treating the severe inflammatory(More)
This paper aims to bridge progress in neuroscience involving sophisticated quantitative analysis of behavior, including the use of robust control, with other relevant conceptual and theoretical frameworks from systems engineering, systems biology, and mathematics. Familiar and accessible case studies are used to illustrate concepts of robustness,(More)
Complex engineered and biological systems share protocol-based architectures that make them robust and evolvable, but with hidden fragilities to rare perturbations. Chaos, fractals, random graphs and power laws inspire a popular view of complexity in which behaviours that are typically unpredictable and fragile 'emerge' from simple interconnections among(More)
Inflammation is a normal, robust physiological process. It can also be viewed as a complex system that senses and attempts to resolve homeostatic perturbations initiated from within the body (for example, in autoimmune disease) or from the outside (for example, in infections). Virtually all acute and chronic diseases are either driven or modulated by(More)
1868 M any of the detailed mechanisms by which bacteria express genes in response to various environmental signals are well-known. The molecular players underlying these responses are part of a bacterial transcriptional regulatory network (BTN). To explore the properties and evolution of such networks and to extract general principles, biologists have(More)
Exogenous erythropoietin (EPO) is a potent neurotrophic factor in vivo, protective against neuronal death in animal models of brain ischemia and human stroke. To date, reports on the distribution of EPO receptor in brain suggest that it is expressed mostly on capillaries. This receptor pattern suggests an indirect effect of EPO on neurons. In these studies,(More)
The correlation of healthy states with heart rate variability (HRV) using time series analyses is well documented. Whereas these studies note the accepted proximal role of autonomic nervous system balance in HRV patterns, the responsible deeper physiological, clinically relevant mechanisms have not been fully explained. Using mathematical tools from control(More)
  • Huagang Hou, Oleg Y Grinberg, Satoshi Taie, Steve Leichtweis, Minoru Miyake, Stalina Grinberg +3 others
  • 2003
UNLABELLED The adequacy of cerebral tissue oxygenation (PtO(2)) is a central therapeutic end point in critically ill and anesthetized patients. Clinically, PtO(2) is currently measured indirectly, based on measurements of cerebrovascular oxygenation using near infrared spectroscopy and experimentally, using positron emission tomographic scanning. Recent(More)
Migraine is a common, little understood, and debilitating disease. It is much more prominent in women than in men (~2/3 are women) but the reasons for female preponderance are not clear. Migraineurs frequently experience severe comorbidities, such as allergies, depression, irritable bowel syndrome, and others; many of the comorbidities are more common in(More)