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New PI(4,5)P2- and membrane proximal integrin–binding motifs in the talin head control β3-integrin clustering
A talin intermolecular interaction autoinhibits its own activation and regulates β3-integrin binding. When bound, β3-integrin undergoes structural alterations that prevent its β and α subunits fromExpand
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Dimerization of Kit‐ligand and efficient cell‐surface presentation requires a conserved Ser‐Gly‐Gly‐Tyr motif in its transmembrane domain
Kit‐ligand (Kitl), also known as stem cell factor, is a membrane‐anchored, noncovalently bound dimer signaling via the c‐kit receptor tyrosine kinase, required for migration, survival, andExpand
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Niche anchorage and signaling through membrane‐bound Kit‐ligand/c‐kit receptor are kinase independent and imatinib insensitive
Kit ligand (KitL) and its tyrosine kinase receptor c‐kit are critical for germ cells, melanocytes, mastocytes, and hematopoietic stem cells. Alternative splicing of KitL generates membrane‐bound KitLExpand
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Membrane‐bound Kit ligand regulates melanocyte adhesion and survival, providing physical interaction with an intraepithelial niche
Morphogenesis, as illustrated by melanocyte migration and homing to the skin, requires cadherin adhesion, integrin‐dependent migration and Kit‐ligand growth factor signaling. However, it is not knownExpand
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Talin-bound NPLY motif recruits integrin-signaling adapters to regulate cell spreading and mechanosensing
β3 integrin residue Y747 is required for cell spreading and paxillin adapter recruitment to substrate-bound integrins in response to substrate stiffness.
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β1D integrin splice variant stabilizes integrin dynamics and reduces integrin signaling by limiting paxillin recruitment
ABSTRACT Heterodimeric integrin receptors control cell adhesion, migration and extracellular matrix assembly. While the α integrin subunit determines extracellular ligand specificity, the β integrinExpand
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The F1 loop of the talin head domain acts as a gatekeeper in integrin activation and clustering
ABSTRACT Integrin activation and clustering by talin are early steps of cell adhesion. Membrane-bound talin head domain and kindlin bind to the β integrin cytoplasmic tail, cooperating to activateExpand