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RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation
In acute promyelocytic leukaemia (APL), the promyelocytic leukaemia (PML) protein is fused to the retinoic acid receptor α (RAR). This disease can be treated effectively with arsenic, which inducesExpand
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Role of promyelocytic leukemia protein in host antiviral defense.
Several pathways have been implicated in the establishment of antiviral state in response to interferon (IFN), one of which implicates the promyelocytic leukemia (PML) protein. The PML gene has beenExpand
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An additional role for SUMO in ubiquitin-mediated proteolysis
Although the post-translational modification of proteins with small ubiquitin-like modifier (SUMO) has a role in many biological processes, it was thought that SUMO, unlike ubiquitin, does not targetExpand
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Large-scale analysis of the meningococcus genome by gene disruption: resistance to complement-mediated lysis.
The biologic role of a majority of the Neisseria meningitidis 2100 predicted coding regions is still to be assigned or experimentally confirmed. Determining the phenotypic effect of gene disruptionExpand
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Characterization of SENP7, a SUMO-2/3-specific isopeptidase.
The modification of proteins by SUMO (small ubiquitin-related modifier) plays important roles in regulating the activity, stability and cellular localization of target proteins. Similar toExpand
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Neuron-restrictive silencer elements mediate neuron specificity of adenoviral gene expression
Neuron–restrictive silencer elements (NRSEs) were used to target the gene expression of adenoviral vectors specifically to neuron cells in the central nervous system. By generating adenoviralExpand
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Multiple crosstalks between mRNA biogenesis and SUMO
AbstractmRNA metabolism involves the orchestration of multiple nuclear events, including transcription, processing (e.g., capping, splicing, polyadenylation), and quality control. This leads to theExpand
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Classic and Variants APLs, as Viewed from a Therapy Response
Most acute promyelocytic leukemia (APL) are caused by PML-RARA, a translocation-driven fusion oncoprotein discovered three decades ago. Over the years, several other types of rare X-RARA fusions haveExpand
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Intranuclear dynamics of the Nup107-160 complex
The Nup107-160 nuclear pore subcomplex (Y-complex) and the chromatin-binding nucleoporin Elys dynamically colocalize with Nup98 and the export factor CRM1 in nuclear GLFG bodies present in HeLaExpand
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An adenovirus encoding CuZnSOD protects cultured striatal neurones against glutamate toxicity
Superoxide dismutase (SOD), a key enzyme in the detoxification of free radicals, catalyses the dismutation of superoxide O2* to oxygen and hydrogen peroxide (H2O2). It is therefore a promisingExpand
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