Marie-Claude Clochard

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Angiogenesis plays a critical role in tumor growth. This phenomena is regulated by numerous mediators such as vascular endothelial growth factor (VEGF). CBO-P11, a cyclo-peptide, has proven to specifically bind to receptors of VEGF and may be used as targeting ligand for tumor angiogenesis. We herein report the design of novel nanoparticles conjugated to(More)
Ion beam shaping is a novel technique with which one can shape nano-structures that are embedded in a matrix, while simultaneously imposing their orientation in space. In this work, we demonstrate that the ion-shaping technique can be implemented successfully to engineer the morphology of hollow metallic spherical particles embedded within a silica matrix.(More)
Differences between the mechanisms of energy deposition by high-LET radiation, consisting of neutrons, protons, alpha particles, and heavy ions on one hand, and low-LET radiation, exemplified by electron beam and gamma radiation on the other, are utilized in the selection of types of radiation used for specific applications. Thus, high-LET radiation is used(More)
Endowing conventional hydrophobic poly(vinylidene fluoride) (PVDF) films with hydrophilic properties was conducted using electron beam irradiation. Grafting of acrylic acid (AA) in/onto pre-irradiated PVDF films was investigated. Reaction parameters, monomer concentration and inhibitor concentration were examined. Radiation grafted films (PVDF-g-PAA) were(More)
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