Marie Cecilie Paasche Roland

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INTRODUCTION Birthweight is used as an indicator of intrauterine growth, and determinants of birthweight are widely studied. Less is known about determinants of deviating patterns of growth in utero. We aimed to study the effects of maternal characteristics on both birthweight and fetal growth in third trimester and introduce placental weight as a possible(More)
INTRODUCTION Maternal nutritional and metabolic factors influence the developmental environment of the fetus. Virtually any nutritional factor in the maternal blood has to pass the placental membranes to reach the fetal blood. Placental weight is a commonly used measure to summarize placental growth and function. Placental weight is an independent(More)
CONTEXT Glucose intolerance in pregnancy predicts an increased risk of future type 2 diabetes. OBJECTIVE The aim of the study was to evaluate glucose metabolism in women with and without gestational diabetes mellitus (GDM) at 5 years follow-up and identify risk factors associated with disturbed glucose metabolism post-partum. DESIGN This follow-up study(More)
OBJECTIVES The placental transfer of nutrients is influenced by maternal metabolic state, placenta function and fetal demands. Human in vivo studies of this interplay are scarce and challenging. We aimed to establish a method to study placental nutrient transfer in humans. Focusing on glucose, we tested a hypothesis that maternal glucose concentrations and(More)
INTRODUCTION Boys have higher morbidity and mortality than girls,particularly when born prematurely, despite higher birthweight. Adaptation to poor intrauterine environment by reducing fetal growth is more prevalent in female than male fetuses. Differences in reponses between the genders might be mediated by placental functions, as illustrated by the(More)
BACKGROUND Preeclampsia is characterized by maternal endothelial dysfunction, which underlies a highly diverse clinical presentation. The pathophysiologic condition remains to be unraveled fully, but interplay between factors that are released from the placenta and maternal vascular vulnerability is likely. An imbalance in circulating angiogenic factors is(More)
tion of sFlt-1 and sEndoglin in preeclampsia patients. Method: Dose and time dependent effects of methyldopa, labetolol, hydralazine and pravastatin were investigated on villous explants cultures of term preeclampsia (PE, n = 3) and matched control (n = 6) placentas obtained from non laboring pregnancies at 10% and 20% oxygen concentration in vitro. sflt-1,(More)
Context Fetuses exposed to an obese intrauterine environment are more likely to be born large-for-gestational age (LGA) and are at increased risk of obesity in childhood and cardiovascular disease and/or type 2 diabetes mellitus as adults, but which factors that influence the intrauterine environment is less clear. Objective To investigate the association(More)
Pre-eclampsia (PE) and gestational diabetes mellitus (GDM) are common complications of pregnancy, but the mechanisms underlying these disorders remain unclear. The aim was to identify the extent of altered gene expression in term placentas from pregnant women with late-onset PE and GDM compared to controls. RNAseq identified few significantly differentially(More)
The human placenta is highly inaccessible for research while still in utero. The current understanding of human placental physiology in vivo is therefore largely based on animal studies, despite the high diversity among species in placental anatomy, hemodynamics and duration of the pregnancy. The vast majority of human placenta studies are ex vivo perfusion(More)