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PURPOSE Little is known about the role of sequence variation in the pathology of HSV-1 keratitis virus. The goal was to show that a multiplex, high-throughput genome-sequencing approach is feasible for simultaneously sequencing seven HSV-1 ocular strains. METHODS A genome sequencer was used to sequence the HSV-1 ocular isolates TFT401, 134, CJ311, CJ360,(More)
Although the idea that entropy alone is su cient to produce an ordered state is an old one in colloidal science [1], the notion remains counter-intuitive and it is often assumed that attractive interactions are necessary to generate phases with long-range order. The phase behaviour for both rods and spheres has been studied experimentally [1, 5, 6, 7, 8, 9,(More)
Infectious diseases are increasingly recognized as an important force driving population dynamics, conservation biology, and natural selection in wildlife populations. Infectious agents have been implicated in the decline of small or endangered populations and may act to constrain population size, distribution, growth rates, or migration patterns. Further,(More)
We present an experimental study of the isotropic-nematic phase transition in an aqueous mixture of charged semiflexible rods ( fd virus) and neutral polymer (Dextran). A complete phase diagram is measured as a function of ionic strength and polymer molecular weight. At high ionic strength we find that adding polymer widens the isotropic-nematic coexistence(More)
Methionine is an important nutrient in animal feed and several approaches have been developed to increase methionine concentration in maize (Zea mays L.) grain. One approach is through traditional breeding using recurrent selection. Using divergent selection, genetically related populations with extreme differences in grain methionine content were produced.(More)
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