Marica Chiara

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Uteroglobin (UG) is a multifunctional protein with anti-inflammatory/immunomodulatory properties. The UG gene is located on the long arm of chromosome 11 (11q12.3–q13.1) in a region linked to some immune disorders. A guanine-adenine substitution at position 38 (A38G) has been found in the noncoding region of exon 1 that is significantly correlated with an(More)
PEMT and CT activities were reciprocally regulated during the perinatal period. Consistently, PEMT2 expression was undetectable before birth when CT was highly expressed. Surprisingly, PEMT2 was relatively highly expressed at birth when the cell division and CT expression were still high. During development liver cell growth was associated with enhanced(More)
Aberrant crypt foci (ACF) are putative preneoplastic lesions of colon cancer which are being utilized currently as a biological end point to evaluate the induction and modulation of colon carcinogenesis. In rodents, caloric restriction reduces carcinogen-induced colon cancer incidence. The present study was designed to investigate the effect of fasting(More)
The effect of fasting/refeeding on MNU-induced mammary carcinogenesis was investigated. Female Sprague-Dawley rats were given i.p. a single dose of MNU (50 mg/Kg body weight) and beginning 1 week after MNU administration were exposed to 3 cycles of 3 days fasting followed by refeeding (10 days). Rats were palpated twice a week and killed when tumor diameter(More)
The purpose of this work was to investigate the effect of fasting on the induction and growth of chemically-induced mammary carcinogenesis. Female Sprague-Dawley rats were given methylnitrosourea (MNU) i.p. (50 mg/kg) at 50 days of age; a group of rats were exposed to 4 day fasting followed by 1 day of refeeding before the administration of the carcinogen,(More)
BACKGROUND Among the possible variables associated with cytokine activation in hemodialysis, filter membrane has been reported to be a major factor and monocytes adherent to the membrane have been suggested as a possible source for cytokine synthesis. METHODS In order to exclude variables other than the direct cell-to-membrane interaction, suspensions of(More)
Previous data of our laboratory showed that female rats regenerated earlier than males and choline shifted the female growth pattern toward that of males. We investigated if the effect of choline on the liver compensatory growth was associated to a modulation of the expression and methylation pattern of an early cell cycle dependent proto-oncogene, c-myc.(More)
The administration of an excess of choline for 3 weeks is able to delay the proliferative response to partial hepatectomy (PH) in female rats. Choline feeding can affect the phospholipid composition of cell membranes and, as a consequence, the transduction of the mitogenic signals. On these bases, we studied the turnover of(More)
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