Maribeth H. Johnson

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Indoleamine 2,3-dioxygenase (IDO) is an immunosuppressive enzyme that contributes to tolerance in a number of biological settings. In cancer, IDO activity may help promote acquired tolerance to tumor antigens. The IDO inhibitor 1-methyl-tryptophan is being developed for clinical trials. However, 1-methyl-tryptophan exists in two stereoisomers with(More)
OBJECTIVE To evaluate the safety and efficacy of a vaccine containing plasmid DNA with an insert encoding human tyrosinase (ie, huTyr vaccine) as adjunctive treatment for oral malignant melanoma (MM) in dogs. ANIMALS 111 dogs (58 prospectively enrolled in a multicenter clinical trial and 53 historical controls) with stage II or III oral MM (modified World(More)
OBJECTIVE The goal of this study was to evaluate the impact of a 10-month after-school physical activity (PA) program on body composition and cardiovascular (CV) fitness in young black girls. RESEARCH METHODS AND PROCEDURES Subjects were 8- to 12-year-olds recruited from elementary schools. Body composition was measured using anthropometrics {waist(More)
In this study, human MCF-7 breast cancer cells, which express functional estrogen and progesterone receptors, were used to compare the efficacy of combined antiestrogen plus antiprogestin therapy to antiestrogen monotherapy. Cells were treated with the antiestrogen 4-hydroxytamoxifen (4-OHT) and/or the antiprogestin mifepristone (MIF) and effects on cell(More)
PURPOSE We determined the degree to which variation in cardiac autonomic modulation was explained by race, sex, moderate-vigorous physical activity (MVPA), cardiovascular fitness (CVF), percent body fat (%BF), waist girth, subcutaneous abdominal adipose tissue (SAAT), and visceral adipose tissue (VAT). METHODS Subjects were 304 adolescents; SAAT and VAT(More)
PURPOSE Television watching has been reported to be associated with obesity, resting energy expenditure, and lower daily physical activity among both children and adolescents. However, most of these studies were based on self report or data collected in laboratory settings. This study examined the relationship among observed time of television watching,(More)
OBJECTIVE To test the hypothesis that third grade children (mean age = 8.7, SD = 0.5) who attended an 8-month after-school program would exhibit favorable changes in body composition, cardiovascular fitness, blood pressure, total cholesterol, and high-density lipoprotein-cholesterol compared with children in control condition. RESEARCH METHODS AND(More)
BACKGROUND AND PURPOSE We have shown that acute treatment with candesartan in an experimental model of stroke resulted in vascular protection and improved outcomes at 24 hours poststroke, but the mechanisms are unknown. We now examine effects of candesartan on proangiogenic factors and 7-day outcomes using the same treatment paradigm. METHODS Male Wistar(More)
BACKGROUND The reliability of ambulatory impedance cardiography has not been evaluated. OBJECTIVE The purpose of this study was to determine the reproducibility of daytime and night-time ambulatory bioimpedance-derived measures of hemodynamic function in youth. METHODS Thirty-five African American adolescents (ages 16.2+/-1.4 years, 14 girls, 21 boys)(More)
OBJECTIVE To evaluate the effect of a 3-year after-school physical activity (PA) intervention on aerobic fitness and percent body fat (%BF). METHODS In total, 18 schools were randomized into intervention or control arms. Measurements were made at the beginning and end of the third, fourth and fifth grades. Fitness was measured with heart rate response to(More)