Mariapaola Sassi

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With the goal of the realization of a primary standard of amount-of-substance fraction of VOC (Volatile Organic Compounds) at trace level, a dynamic generator is constructed, based on the diffusion phenomena, according to ISO 6145-8. Generator will be followed by a dilution system. In the present paper, generator performances are discussed. The analysis of(More)
Cytomorphological- and immunofluorescence-based methods are currently use for the diagnosis of malignant human tumors. However, morphological overlaps between tumor and normal cell types frequently occur. Recently, a change in cell elasticity of tissues has been recognized as a marker of tissues metastatic potential. Atomic force Microscope (AFM) can(More)
Lipids and lipoproteins concentration in human plasma are directly correlated to the risk of C cardiovascular diseases. Enumeration of certain classes of lipoproteins by their size, e.g. mean and modal diameter, wants to be developed in alternative of the traditionally used method based of their density. Traceable size measurement of certified nanospheres(More)
Pharmaceutical industries have declared their need of metrology in the cellular field, to improve new drugs developing time and costs by high-content screening technologies. Cell viability and proliferation tests largely use confluency of cells on a bi-dimensional (2D) surface as a biological measurand. The confluency is measured from images of 2D surface(More)
This report focuses on the characterization of CD4 expression level in terms of equivalent number of reference fluorophores (ERF). Twelve different flow cytometer platforms across sixteen laboratories were utilized in this study. As a first step the participants were asked to calibrate the fluorescein isothiocyanate (FITC) channel of each flow cytometer(More)
Exposure assessment may be performed by ambient air monitoring and by biological monitoring (BM) of body fluids. The main analytical technique in BM, for the analysis of Volatile Organic Compounds (VOCs) in blood and urine, is the static head-space technique followed by capillary gas chromatography with different detectors. The actual measurement(More)
Human mesenchymal stem cells are a good candidate to repair and to regenerate tissues for regenerative medicine applications. Their use in combination with 3D scaffolds has been largely studied in vitro to characterize their properties and differentiation potential prior to apply them in vivo. One of the most important clues in vitro is given by their(More)
Recent studies recognized the cell stiffness changes as a marker for cancer detection. Reliable and reproducible measurements of elastic modulus, mapping different cell regions are the basis for developing a new methodology for cancer detection. To this aim, a metrological characterized AFM microscope has been developed, micro- and nano-indentation of soft(More)
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