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BACKGROUND Exposure to environmental tobacco smoke (ETS) increases the risk of respiratory illness in children but data are inconclusive regarding the risk of IgE sensitisation. OBJECTIVE To elucidate whether exposure to smoking prenatally and/or postnatally is related to IgE sensitisation in children at 4 years of age. METHODS As part of a prospective(More)
BACKGROUND Subcutaneous allergen-specific immunotherapy frequently causes allergic side effects and requires 30 to 80 injections over 3 to 5 years. OBJECTIVE We sought to improve immunotherapy by using intralymphatic allergen administration (intralymphatic immunotherapy [ILIT]) and by targeting allergen to the MHC class II pathway. METHODS Recombinant(More)
BACKGROUND Evidence on the long-term effects of air pollution exposure on childhood allergy is limited. OBJECTIVE We investigated the association between air pollution exposure and allergic sensitization to common allergens in children followed prospectively during the first 10 years of life. METHODS Five European birth cohorts participating in the(More)
BACKGROUND The anthroposophic lifestyle has several features of interest in relation to allergy: for example, a restrictive use of antibiotics and certain vaccinations. In a previous Swedish study, Steiner school children (who often have an anthroposophic lifestyle) showed a reduced risk of atopy, but specific protective factors could not be identified. (More)
BACKGROUND We have performed a double-blind, placebo-controlled injection immunotherapy study with genetically modified derivatives of the major birch pollen allergen, Bet v 1 (Bet v 1-trimer, Bet v 1-fragments). OBJECTIVE To investigate whether vaccination with genetically modified allergens induces allergen-specific antibodies in nasal secretions and to(More)
BACKGROUND The role of exposure to air pollution in the development of allergic sensitization remains unclear. OBJECTIVE We sought to assess the development of sensitization until school age related to longitudinal exposure to air pollution from road traffic. METHODS More than 2500 children in the birth cohort BAMSE (Children, Allergy, Milieu,(More)
BACKGROUND Allergens from cat are among the most potent elicitors of allergic disease. Four cat allergens have been identified; however, evidence indicates the existence of additional allergens. OBJECTIVE In this study, we evaluated IgE sensitization to IgA from cat. METHODS Sera from cat-sensitized patients (n = 81) were analyzed for IgE antibodies to(More)
Inflammatory bowel disease (IBD) can be treated effectively by anti-tumour necrosis factor (TNF) therapy. We set out to investigate the unclear immunoregulatory mechanisms of the treatment. Thirty-four patients with IBD treated with anti-TNF were included. Lymphocytes from peripheral blood and intestinal biopsies were analysed by flow cytometry. Regulation(More)
BACKGROUND House dust mites (HDM) Dermatophagoides pteronyssinus are a frequent indoor allergen source. Our aim was to determine the frequencies of IgE reactivity to purified HDM allergen molecules in mite allergic patients from different parts of Europe in order to establish an allergen panel for diagnosis of HDM allergy. MATERIALS AND METHODS(More)
BACKGROUND In recent years, studies have shown a protective effect of being raised in a farm environment on the development of hay fever and atopic sensitization. Inconsistent data on the relation of farming to asthma and wheeze have raised some doubt about a true protective effect. OBJECTIVE We sought to study the differential effects of farm-associated(More)