Marianne Sieg

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Comparisons of aromatic amine activation were made by using intact cells or cell homogenates (S-9) from bovine bladder urothelium and liver. Since both liver and bladder are thought to contribute carcinogenic metabolites for bladder cancer initiation, comparisons of these two organs' relative ability to activate aromatic amines to mutagens were made.(More)
A bovine bladder cell-mediated mutagenesis system using Chinese hamster V79 cells and Salmonella typhimurium as target organisms was developed to investigate the capacity of the bladder urothelium to activate chemical carcinogens. Bovine bladder epithelial cells can activate the aromatic amines AF and 4-ABP to intermediates which mutate V79 cells and S.(More)
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