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  • M Schou
  • 1998
Prophylactic lithium treatment lowers the frequency of recurrences in manic depressive illness. Does it also reduce mortality and suicidal behavior? In this paper all relevant publications were reviewed. The mortality of lithium-treated patients was compared with the mortality in the general population, and the patients' suicidal behavior when they were on(More)
  • M Schou
  • 2001
The paper reviews briefly and comments in detail on selected events in the history of lithium treatment. The events include Cade's discovery of lithium's antimanic action, the discovery and establishment of its prophylactic action, the ensuing debate, amelioration and prevention of side effects and risks, use during pregnancy, non-compliance, selection of(More)
Kidney function has been examined in 237 patients who in the autumn of 1977 were in lithium treatment at the Psychiatric Hospital in Risskov, most of them as outpatients. The average age was 42 years. The patients had been given lithium treatment for 0.5-17 years, mean duration 5 years. The mean lithium dosage was 33 mmol/day and the mean 12-hour serum(More)
  • M Schou
  • 1984
A combined literature study and correspondence follow-up provided information about the development and further course of long-lasting neurological sequelae after lithium intoxication in 40 patients (28 women and 12 men). The circumstances surrounding the acute intoxications were examined. Possible precipitating circumstances included somatic illness with(More)
Analysis of more than 350 observations of patients who had been under lithium treatment for 6 months to 4 years showed a significant negative correlation between dosage requirements and age; old patients required less lithium than young patients to maintain a particular serum lithium concentration. The decline in dosage requirement with increasing age could(More)
The mortality of patients suffering from affective disorders is much higher than that of the general population; this excess is due to both suicides and cardiovascular disease. During long-term lithium treatment, the overall mortality has not been found to differ significantly from that of the general population but the question remains whether this(More)