Learn More
Dendritic cells (DC) are essential to the initiation of an immune response due to their unique ability to take-up and process Ag, translocate to lymph nodes, and present processed Ag to naive T cells. Many chemokines, chemokine receptors and other G protein-coupled receptors (GPCRs) are implicated in these various aspects of DC biology. Through microarray(More)
BACKGROUND Human monoclonal antibodies (mAbs) generated as a result of the immune response are likely to be the most effective therapeutic antibodies, particularly in the case of infectious diseases against which the immune response is protective.Human cytomegalovirus (HCMV) is an ubiquitous opportunistic virus that is the most serious pathogenic agent in(More)
Leukemia-derived human myeloid cell lines, such as the promyelocytic HL-60 (1) and ML3 (2), and the histiocytic U937 (3), are often used as models to study terminal differentiation of myelomonocytic cells. DMSO (4), retinoic acid (RA)' (5), and other substances induce HL-60 cells to differentiate along the myeloid lineage, whereas 12-o-tetradecanoyl(More)
Tumor necrosis factor (TNF)' and lymphotoxin (LT) are two partially homol-ogous factors originally described on the basis of their cytotoxic or cytostatic effects on tumor cell lines (1-3). Purification studies and cloning of genes for TNF and LT have allowed more detailed studies of the biology of these factors (4-8). In addition to their cytotoxic(More)
  • 1