Marianne M. Zupanc

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In contrast to mammals, teleost fish exhibit an enormous potential to continuously produce new neurons in many areas of the adult brain, and to regenerate neural tissue after brain injury. The regenerative capability of the teleost fish brain is based upon a series of well-orchestrated individual processes, including: elimination of damaged cells by(More)
In contrast to mammals, fish maintain their capacity to generate neurons in the central nervous system even during adulthood for prolonged periods of life. By employing immunohistochemical, autoradiographic, and electron microscopic techniques, we studied such a postnatal neurogenesis within the complex of the central posterior/prepacemaker nucleus (CP/PPn)(More)
The neuropeptide somatostatin (SS) and its binding sites display a wide distribution in the central nervous system of vertebrates. By employing semi-quantitative autoradiography, we identified such binding sites in the brain of the weakly electric fish Apteronotus leptorhynchus (Gymnotiformes, Teleostei). Whereas (SS1) binding sites for the octapeptide(More)
Sexually dimorphic behaviors develop under the influence of sex steroids, which induce reversible changes in the underlying neural network of the brain. However, little is known about the proteins that mediate these activational effects of sex steroids. Here, we used a proteomics approach for large-scale identification of proteins involved in the(More)
Teleost fish are distinguished by their enormous potential for the generation of new cells in both the intact and the injured adult brain. Here, we present evidence that these cells are a genetic mosaic caused by somatic genomic alteration. Metaphase chromosome spreads from whole brains of the teleost Apteronotus leptorhynchus revealed an euploid complement(More)
The distribution of somatostatin mRNA in the brain of Apteronotus leptorhynchus, a weakly electric gymnotiform fish, has been mapped by employing in situ hybridization with an oligodeoxynucleotide probe corresponding to nucleotides 1-26 of catfish somatostatin mRNA; this probe was end-labelled with digoxigenin. Most labelled cell groups were found in the(More)
Exploration of the molecular dynamics underlying regeneration in the central nervous system of regeneration-competent organisms has received little attention thus far. By combining a cerebellar lesion paradigm with differential proteome analysis at a post-lesion survival time of 30 min, we screened for protein candidates involved in the early stages of(More)
Theodore H. Bullock (1905–2005) was a pioneer of integrative and comparative neurobiology and one of the founders of neuroethology. His work—distinguished by the tremendous number of different research themes and animal taxa studied—provided the basis for a comprehensive analysis of brain evolution. Among his major achievements are: one of the first(More)
In contrast to mammals, fish are distinguished by their enormous potential for brain repair after injuries. This phenomenon has been well studied after application of stab-wound lesions to the corpus cerebelli, a cerebellar subdivision, in the teleost fish Apteronotus leptorhynchus. By combining this lesion paradigm with immunohistochemical staining, we(More)
25 Sexually dimorphic behaviors develop under the influence of sex steroids, which induce 26 reversible changes in the underlying neural network of the brain. However, little is known about 27 the proteins that mediate these activational effects of sex steroids. Here, we used a proteomics 28 approach for large-scale identification of proteins involved in(More)