Marianne Garland

Learn More
Direct observational data on the development of the brains of human and nonhuman primates is on remarkably scant, and most of our understanding of primate brain development is extrapolated from findings in rodent models. Magnetic resonance imaging (MRI) is a promising tool for the noninvasive, longitudinal study of the developing primate brain. We devised a(More)
During pregnancy, exposure to nicotine and other compounds in cigarette smoke increases the risk of the sudden infant death syndrome (SIDS) two- to fivefold. Serotonergic (5-HT) abnormalities are found, in infants who die of SIDS, in regions of the medulla oblongata known to modulate cardiorespiratory function. Using a baboon model, we tested the hypothesis(More)
OBJECTIVE To test the hypothesis that local coherence in extra-dural EEG recordings, a direct measure of synchronous cortical network activity, oscillates with the same periodicity as EEG power cycling and follows a similar developmental trajectory. METHODS Local coherence was derived from continuous EEG recordings from closely spaced (1 cm) chronically(More)
Magnetic Resonance Imaging (MRI) is a promising tool for the noninvasive, longitudinal study of developing primate brains. We developed a protocol to scan pregnant baboons serially at 3T for up to 3h per session. This protocol includes procedures for animal preparation, anesthesia, MRI scanning, and post-scan animal care. We applied this protocol to scan 5(More)
Exposure to nicotine during pregnancy via maternal cigarette smoking is associated with visual deficits in children. This is possibly due to the activation of nicotinic acetylcholine receptors (nAChRs) in the occipital cortex, which are important in the development of visual mapping. Using a baboon model, we explored the effects of prenatal nicotine on(More)
BACKGROUND Preterm infants are at high risk for adverse neurodevelopmental and behavioral outcomes. Family Nurture Intervention (FNI) in the Neonatal Intensive Care Unit (NICU) is designed to counteract adverse effects of separation of mothers and their preterm infants. Here, we evaluate effects of FNI on neurobehavioral outcomes. METHODS Data were(More)
41 During pregnancy, exposure to nicotine and other compounds in cigarette smoke increases 42 the risk of the sudden infant death syndrome (SIDS) 2-5-fold. Serotonergic (5-HT) abnormalities are 43 found in infants that die of SIDS in regions of the medulla oblongata known to modulate 44 cardiorespiratory function. Using a baboon model, we tested the(More)
Previous work in female mice has shown that suckling stimulation is essential for the initiation of male-directed aggression during the immediate postpartum period. The present work examined the importance of this stimulus for the maintenance of aggression during lactation. Surgical excision of nipples (thelectomy) on Postpartum Day 5 accelerates the(More)
  • 1