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CONTEXT Elevated nonfasting triglycerides indicate the presence of remnant lipoproteins, which may promote atherosclerosis. OBJECTIVE To test the hypothesis that very high levels of nonfasting triglycerides predict myocardial infarction (MI), ischemic heart disease (IHD), and death. DESIGN, SETTING, AND PARTICIPANTS A prospective cohort study of 7587(More)
BACKGROUND Elevated lipoprotein(a) levels are associated with myocardial infarction (MI) in some but not all studies. Limitations of previous studies include lack of risk estimates for extreme lipoprotein(a) levels, measurements in long-term frozen samples, no correction for regression dilution bias, and lack of absolute risk estimates in the general(More)
CONTEXT We have previously shown that rare mutations in the apolipoprotein B gene (APOB) may result in not only severe hypercholesterolemia and ischemic heart disease but also hypocholesterolemia. Despite this, common single-nucleotide polymorphisms (SNPs) in APOB have not convincingly been demonstrated to affect low-density lipoprotein (LDL) cholesterol(More)
BACKGROUND Active platelets are large and contribute to development of myocardial infarction (MI). Platelet size is measured automatically as mean platelet volume (MPV) together with platelet count. OBJECTIVES We tested the hypothesis that increased MPV is associated with risk of MI in the general population independent of known cardiovascular risk(More)
OBJECTIVES The aim of this study was to test the hypothesis that elevated nonfasting remnant cholesterol is a causal risk factor for ischemic heart disease independent of reduced high-density lipoprotein (HDL) cholesterol. BACKGROUND Elevated remnant cholesterol is associated with elevated levels of triglyceride-rich lipoproteins and with reduced HDL(More)
CONTEXT The diagnosis of familial hypercholesterolemia (FH) can be made using the Dutch Lipid Clinic Network criteria. This employs the personal and family history of premature coronary artery disease and hypercholesterolemia and the presence of a pathogenic mutation in the low-density lipoprotein receptor (LDLR) and apolipoprotein B (APOB) genes. (More)
We followed 13,981 Danes for 26 years, during which 1,793 developed myocardial infarction and 7,818 died. Women with elevated non-fasting triglycerides had hazard ratios for myocardial infarction of 2.2 for triglycerides of 1-1.99 mmol/L, 4.4 for 2-2.99 mmol/L, 3.9 for 3-3.99 mmol/L, 5.1 for 4-4.99 mmol/L, and 17 for > or = 5 mmol/L versus women with(More)
OBJECTIVE We tested the hypothesis that low plasma concentrations of 25-hydroxyvitamin D are associated with increased risk of symptomatic ischemic stroke in the general population. METHODS We measured plasma 25-hydroxyvitamin D in 10,170 individuals from the general population, the Copenhagen City Heart Study. During 21 years of follow-up, 1,256 and 164(More)
BACKGROUND Adiposity, assessed as elevated body mass index (BMI), is associated with increased risk of ischemic heart disease (IHD); however, whether this is causal is unknown. We tested the hypothesis that positive observational associations between BMI and IHD are causal. METHODS AND FINDINGS In 75,627 individuals taken from two population-based and one(More)
BACKGROUND Apolipoprotein B (apoB) levels predict fatal myocardial infarction. Whether apoB also predicts nonfatal ischemic cardiovascular events is unclear. We tested the following hypotheses: apoB predicts ischemic cardiovascular events, and apoB is a better predictor of ischemic cardiovascular events than low-density lipoprotein cholesterol. METHODS(More)