Mariana Pino

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Inverse agonists are ligands that are capable of repressing basal receptor activity in the absence of an agonist. We have designed a series of C-1-substituted acetylenic retinoids that exhibit potent antagonism of retinoic acid receptor (RAR)-mediated transactivation. Comparison of these related retinoid antagonists for their ability to repress basal RAR(More)
A multicenter survey, carried out in 2010 in Argentina, showed an increased prevalence of extended-spectrum β-lactamase (ESBL)-producing enterobacteria, with some changes in the molecular epidemiology of circulating ESBLs. While enzymes of the CTX-M-2 group remain endemic, the emergence of CTX-M-15 and of enzymes of the CTX-M-8 and CTX-M-9 groups was(More)
Hepatic alcohol dehydrogenase was measured in liver homogenates from normal, moderate drinkers, and from alcoholics with normal livers, steatosis, and liver cirrhosis. Hepatic alcohol-dehydrogenase activity was 0.37±0.12 µM/hr./mg. of protein in the normals, 0.18±0.13 µM/hr/mg. in alcoholics with normal liver histology, 0.12±0.09 µM/hr./mg. in alcoholics(More)
The effects of clopamide, pindolol and its combination on plasma lipids in 49 hypertensive patients (WHO I-II), divided into three parallel randomized groups, were studied over a 6 months period. Total cholesterol, triglycerides, HDL and LDL cholesterol fractions were determined twice during an initial 4-week washout phase, and after a 1-, 3- and 6-month(More)