Mariana Lopes dos Santos

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NaPi2b, a sodium-dependent phosphate transporter, is highly expressed in ovarian carcinomas and is recognized by the murine monoclonal antibody MX35. The antibody had shown excellent targeting to ovarian cancer in several early phase clinical trials but being murine the antibody's full therapeutic potential could not be explored. To overcome this impediment(More)
Background A successful monoclonal antibody (mAb) cell line development requires efficient clone detection and screening. Cloning by limiting dilution (LDC) is the traditional method to isolate mAbs expressing clones [1]. Although effective, LDC is time-consuming, with limited workflow and therefore a critical step of cell line development. To compare to(More)
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