Marian van der Meulen

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OBJECTIVE To identify the neural underpinnings of cognitive deficits associated with memory problems in amnestic mild cognitive impairment (aMCI). BACKGROUND Functional magnetic resonance imaging (fMRI) is increasingly used to assess patients with aMCI and could potentially help predict conversion to Alzheimer disease, but imaging results so far have been(More)
BACKGROUND Aging is often associated with modifications of gait. Recent studies have revealed a strong relationship between gait and executive functions in healthy and pathological aging. We hypothesized that modification of gait due to aging may be related to changes in frontal lobe function. METHODS Fourteen younger (27.0±3.6 years) and 14 older healthy(More)
Motor imagery (MI) is often used in combination with neuroimaging techniques to study the cognitive control of gait. However, imagery ability (IA) varies widely across individuals, potentially influencing the pattern of cerebral recruitment during MI. The aim of the current study was to investigate this effect of IA on the neural correlates of gait control(More)
Using a modified version of the Virtual Errands Task (VET; McGeorge et al. in Presence-Teleop Virtual Environ 10(4):375-383, 2001), we investigated the executive ability of multitasking in 18 high-functioning adolescents with ASD and 18 typically developing adolescents. The VET requires multitasking (Law et al. in Acta Psychol 122(1):27-44, 2006) because(More)
The BABYTALK BT-45 system generates tex-tual summaries of clinical data about babies in a neonatal intensive care unit. A recent task-based evaluation of the system suggested that these summaries are useful, but not as effective as they could be. In this paper we present a qualitative analysis of problems that the evaluation highlighted in BT-45 texts. Many(More)
It has been shown that summarizing complex multi-channel physiological and discrete data in natural language (text) can lead to better decision-making in the intensive care unit (ICU). As part of the BabyTalk project, we describe a prototype system (BT-45) which can generate such textual summaries automatically. Although these summaries are not yet as good(More)
Alzheimer's disease is a neurodegenerative disease characterized by senile plaques, neurofibrillary tangles, synaptic loss, neuronal death and cholinergic deficits, causing cognitive, behavioral and psychological deficits, as well as a functional impairment that results in serious caregiver distress and a great economic burden worldwide. High hopes rose(More)
Three experiments tested the hypothesis that activation of semantic memory from perceptual input does not require initial retention of the perceptual material in working memory as assumed by a widely held view of information processing. In Expt 1, two brain-damaged patients with left-sided unilateral spatial neglect were tested. They were asked to listen to(More)
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