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Cardiovascular disease (CVD) is the leading cause of death worldwide. Recent genome-wide association (GWA) studies have pinpointed many loci associated with CVD risk factors in adults. It is unclear, however, if these loci predict trait levels at all ages, if they are associated with how a trait develops over time, or if they could be used to screen(More)
OBJECTIVES To identify genetic factors that would be predictive of individuals who require an implantable cardioverter-defibrillator (ICD), we conducted a genome-wide association study among individuals with an ICD who experienced a life-threatening arrhythmia (LTA; cases) vs. those who did not over at least a 3-year period (controls). BACKGROUND Most(More)
Kin Chung Fong, Emma E. Wollman, Harish Ravi, Wei Chen, Aashish A. Clerk, M.D. Shaw, H. G. Leduc, and K. C. Schwab* Kavli Nanoscience Institute, California Institute of Technology, MC 128-95, Pasadena, California 91125, USA Department of Physics, McGill University, Montreal H3A 2T8, Canada Jet Propulsion Laboratory, California Institute of Technology,(More)
Microarray-based gene expression analysis of peripheral whole blood is a common strategy in the development of clinically relevant biomarker panels for a variety of human diseases. However, the results of such an analysis are often plagued by decreased sensitivity and reliability due to the effects of relatively high levels of globin mRNA in whole blood.(More)
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