Marian Różycki

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The melanocortin-4 receptor (MC4R) is involved in feed intake regulation. A missense mutation G/A in position 1426, which causes Asp-Asn substitution at position 298 in the MC4R gene has been associated with feed intake, fatness and growth, however published results of its effect are inconsistent. In our study we evaluated an effect of missense mutations on(More)
IGF2 is one of the genes that control muscle development. Moreover,IGF2 is imprinted, as only the paternal allele is expressed in the offspring. Using real-time PCR forIGF2 genotyping (Carrodegous et al. 2005), we evaluated the frequency of theIGF2 A3072G mutation (Van Laere et al. 2003) in pigs: Polish Landrace (PL,N = 271) and Large White (LW,N = 267).(More)
Three non-synonymous single nucleotide polymorphisms (T221C, T232A and C233T) were detected in exon 4 of the porcine leptin receptor (LEPR) gene. The T232A substitution could be identified as a (Tsp509I) restriction fragment length polymorphism. The frequency of genotype TT varied in six genetic groups from 0.62 (Duroc) to 0.99 (Polish Large White).(More)
The main function of adipose tissue is energy storage and production of various cytokines and hormones, such as leptin. Leptin is a protein hormone synthesized and secreted by adipose tissue. The expression of leptin is strongly dependent on growth and luteinizing hormones, which play an important role in the brain-pituitary axis. The concentration of(More)
Genes MYOD1 and MYF5 of the MyoD family were considered as candidate genes for growth rate and carcass traits in pigs. Products of both genes are transcription factors with domain bHLH. A relation was estimated between new polymorphisms identified in the coding and 5’ flanking regions of both genes and productive traits of 216 gilts of synthetic Line 990.(More)
MYOG andMYF6 belong to theMyoD gene family. They code for the bHLH transcription factors playing a key role in later stages of myogenesis: differentiation and maturation of myotubes. Three SNPs in porcineMYF6 and two in porcineMYOG were analysed in order to establish associations with chosen carcass quality and growth rate traits in Polish Landrace, Polish(More)
The Drosophila-like homolog 1 (DLK1), a transmembrane signal protein similar to other members of the Notch/Delta/Serrate family, regulates the differentiation process in many types of mammalian cells. Callipyge sheep and DLK1 knockout mice are excellent examples of a fundamental role of the gene encoding DLK1 in muscle growth and fat deposition. DLK1 is(More)
The aim of this study was to obtain information on the possible influence of the bovine growth hormone gene (bGH) on gametogenesis and reproductive parameters of a 2-year-old Polish Landrace transgenic boar. The bGH gene construct had been introduced into the zygote of the boar with the use of the microinjection technique. On the basis of the available(More)
DLK1--(Drosophila like element 1) is a paternally expressed gene, associated with the callipyge phenotype in sheep. In a present study we designed a new real-time PCR alleleic discrimination assay for genotyping of a silent C/T mutation (c.639C>T) in DLK1 gene in swine. The DLK1 c.639C>T mutation was highly polymorphic in all breeds analyzed and C allele(More)
Populations of wild boar (Sus scrofa scrofa L.) of Central Europe frequently demonstrate polymorphism in chromosome number. This phenomenon is caused by chromosome rearrangements of the centric fusion type. The presence of Robertsonian translocations in the wild boar population may lead to one of three different karyotypes: 2n=36, 2n=37 and 2n=38. The aim(More)