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An application pull has occurred in biomedicine with the move to in silico studies, which augment in vivo and in vitro studies by simulating more details of biomed-ical processes. Using these simulated processes helps medical doctors make decisions by exploring different scenarios. Preoperative simulation and visualization of vascular surgery 3 and expert(More)
Automatic composition of workflows from Web and Grid services is an important challenge in today's distributed applications. The system presented in this paper supports the user in composing an application workflow from existing Grid services. The flow composition system builds workflows on an abstract level with semantic and syntactic descriptions of(More)
This article presents the design and feasibility of a system that supports execution of High Level Architecture (HLA)–distributed interactive simulations in an unreliable Grid environment. The article presents an overall architecture of a system based on experience gained from previous designs. The most important operational components of the system are(More)
We present a prototype of the flood early warning system (EWS) developed within the UrbanFlood FP7 project. The system monitors sensor networks installed in flood defenses (dikes, dams, embankments, etc.), detects sensor signal abnormalities, calculates dike failure probability, and simulates possible scenarios of dike breaching and flood propagation. All(More)