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The effects of aging on visuospatial attention were investigated with event-related brain potentials (ERPs). A central arrow pointed towards (75% valid cues) or away from (25% invalid cues) the location of upcoming visual targets to which subjects made two choice discriminations. Young and older adults responded faster following valid than invalid cues. The(More)
OBJECTIVE The purpose of the study was to develop a standardized instrument, the Behavior Rating Scale for Dementia, for rating psychopathology in patients with probable Alzheimer's disease and to conduct a multicenter pilot study of this instrument. METHOD The rating scale was developed collaboratively on the basis of clinical experience and existing(More)
Assessment of activities of daily living (ADL) in Alzheimer disease (AD) is critical in establishing the diagnosis, monitoring disease progression, evaluating the efficacy of treatment interventions, and determining the need for health and social services. The proper method to measure ADL depends on the purposes to which the scale is to be put. Existing ADL(More)
OBJECTIVES To evaluate if caregivers are reliable informants concerning memory deficits in patients with Alzheimer's disease (AD). DESIGN Responses of caregivers of patients with probable AD and responses of healthy control subjects on a standardized memory questionnaire were compared with objective measures of cognition (Consortium to Establish a(More)
OBJECTIVE To present and evaluate an instrument, the Telephone Cognitive Assessment Battery (TCAB), designed to be administered over the telephone to assess the cognitive status of older individuals. The TCAB addresses mental status, reasoning and executive ability, primary and secondary memory, and language. It consists of six neuropsychological tests and(More)
OBJECTIVES To identify clinically meaningful change in longitudinal assessment. DESIGN A novel approach that qualifies item-level change over time by the degree to which it is clinically meaningful. SETTING The classification method was tested by applying it to changes over 12 months in the frequency ratings of the items of a behavioral assessment(More)
Noncognitive behavioral symptoms occurring during the prior week were studied in 34 Alzheimer's disease (AD) patients and 21 spousal control subjects via caregiver and patient interviews using the Behavioral Pathology in Alzheimer's Disease Rating Scale and the Cornell Scale for Depression in Dementia. Delusional or paranoid features were reported in 13(More)
Visual hallucinations (VH) are the most common hallucinations in Alzheimer's disease (AD), but their relationships with other behavioral symptoms and measures of cognitive performance are unclear. Using the BE-HAVE/AD, a semistructured behavioral inventory, we identified 20/160 AD patients (13%) who were currently having VH. Patients with VH performed worse(More)
Our study was designed to evaluate perceptual ability measured by the Gollin Incomplete Pictures Test (in which subjects identify fragmented pictures of common objects) in Alzheimer Disease. We developed a standardized procedure for administering Gollin's test and compared the performance of 58 Alzheimer patients and 37 elderly controls on the Gollin, two(More)