Marian B Patterson

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The effects of aging on visuospatial attention were investigated with event-related brain potentials (ERPs). A central arrow pointed towards (75% valid cues) or away from (25% invalid cues) the location of upcoming visual targets to which subjects made two choice discriminations. Young and older adults responded faster following valid than invalid cues. The(More)
OBJECTIVE The purpose of the study was to develop a standardized instrument, the Behavior Rating Scale for Dementia, for rating psychopathology in patients with probable Alzheimer's disease and to conduct a multicenter pilot study of this instrument. METHOD The rating scale was developed collaboratively on the basis of clinical experience and existing(More)
Assessment of activities of daily living (ADL) in Alzheimer disease (AD) is critical in establishing the diagnosis, monitoring disease progression, evaluating the efficacy of treatment interventions, and determining the need for health and social services. The proper method to measure ADL depends on the purposes to which the scale is to be put. Existing ADL(More)
OBJECTIVES To evaluate if caregivers are reliable informants concerning memory deficits in patients with Alzheimer's disease (AD). DESIGN Responses of caregivers of patients with probable AD and responses of healthy control subjects on a standardized memory questionnaire were compared with objective measures of cognition (Consortium to Establish a(More)
The purpose of this study was to examine the effects, over time, of depressive symptoms in persons with Alzheimer's disease on depression in their family caregivers. In a sample of 353 patients and caregivers, multilevel longitudinal analysis was used to accommodate an observational design in which the number of observation points and the intervals between(More)
OBJECTIVE To examine one model of research advance directive as a possible way to reduce the mismatch between patient and proxy choices and also to learn more about how patients with mild to moderate dementia may want to keep decision making or cede it to their proxies in the future. METHODS Separate interviews were conducted with 149 dyads of dementia(More)
OBJECTIVE To present and evaluate an instrument, the Telephone Cognitive Assessment Battery (TCAB), designed to be administered over the telephone to assess the cognitive status of older individuals. The TCAB addresses mental status, reasoning and executive ability, primary and secondary memory, and language. It consists of six neuropsychological tests and(More)
OBJECTIVES To assess differences in resource use and cost between older adults with and without mild cognitive impairment (MCI) over time. DESIGN Multicenter, longitudinal study. SETTING Sixty-eight Alzheimer's Disease Cooperative Study (ADCS) sites in the United States. PARTICIPANTS Two hundred fifty-nine individuals diagnosed with MCI and 107(More)