Mariama Diatta

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We investigated the role of DC-SIGN (CD209), long pentraxin 3 (PTX3) and vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) in susceptibility to pulmonary tuberculosis (TB) in 321 TB cases and 347 healthy controls from Guinea-Bissau. Five additional, functionally relevant SNPs within toll-like receptors (TLRs) 2, 4 and 9 were typed but(More)
We conducted a three-year entomologic study in Dielmo, a village of 250 inhabitants in a holoendemic area for malaria in Senegal. Anophelines were captured on human bait and by pyrethrum spray collections. The mosquitoes belonging to the Anopheles gambiae complex were identified using the polymerase chain reaction. Malaria vectors captured were An.(More)
The ecology, population dynamics, and malaria vector efficiency of Anopheles gambiae and An. arabiensis were studied for 2 yr in a Sahelian village of Senegal. Anophelines were captured at human bait and resting indoors by pyrethrum spray. Mosquitoes belonging to the An. gambiae complex were identified by polymerase chain reaction. Of 26,973 females, An.(More)
The choice of appropriate artemisinin-based combination therapy depends on several factors (cost, efficacy, safety, reinfection rate and simplicity of administration). To assess whether the combination dihydroartemisinin-piperaquine (DP) could be an alternative to artemether-lumefantrine (AL), the efficacy and the tolerability of the two products for the(More)
From 1993 to 1996, an entomological survey was conducted in the village of Ndiop, Senegal, as part of a research programme on malaria epidemiology and the mechanisms of protective immunity. Mosquitoes were captured on human bait and by indoor spraying. Species from the Anopheles gambiae complex were identified using the polymerase chain reaction, and(More)
Variation at nine microsatellite loci was investigated to understand how Anopheles arabiensis populations survive the dry season in the sahelian region of Senegal. Low estimates of genetic differentiation (F(ST) = 0.012, R(ST) = 0.009) between two populations, 250 km apart, suggested extensive gene flow across this distance. Despite extreme seasonal(More)
This study in Senegal compared the feeding preferences of Anopheles gambiae and A. arabiensis while controlling for equal accessibility to hosts located outdoors under bed net traps. All fed A. gambiae complex females were identified with the aid of the polymerase chain reaction and their blood meal sources were identified by enzyme-linked immunosorbent(More)
Rheumatoid arthritis is the most frequent inflammatory rheumatism disease. Several studies were aimed to understand its physiopathogenesis in particular the association between some HLA-DR alleles and rheumatoid arthritis. A prospective study was carried out in 34 patients suffering from RA (30 Women and 4 men). The diagnosis was clinically and(More)
Some informations about malaria transmission, which has until nox difficult to get, can be obtained thanks to the use of molecular biology tools, PCR mainly. In Senegal, we use that technique to solve two kinds of problems: -Identification of species of the Anopheles gambiae complex: PCR technique is useful compared to other diagnostic methods (chromosome(More)