Mariam Chipashvili

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Anti-ischemic effects of NO releasing by nitroglycerin (NTG) and the release of calcitonin gene-related peptide (CGRP) are involved in the decrease of vascular remodeling in different cardiovascular diseases. Using a nitrate-free period is still generally required to prevent nitrate tolerance and should be used as the first-line option to maintain adequate(More)
Quantitative distribution of bioactive substances in the brain of aggressive rats was studied. The norepinephrine/serotonin ratio increased in the temporal and parietal lobes, hypothalamus, and hippocampus of killer rats. The open filed behavior of aggressive rats is characterized by a long latency period, low locomotor activity, and slow movements.(More)
Chlorpromazine was shown to inhibit non-competitively the 3H-GABA uptake both by the glial cells and synaptosomes; synaptosomal uptake was more sensitive to the inhibitor. Only the low-affinity GABA uptake in the glial cells was competitively inhibited by beta-alanine. On the whole, there was a correlation between the inhibition of GABA uptake by(More)
Chlorpromazine noncompetitively inhibits the uptake of GABA-3H by both glial cells and synaptosomes, synaptosomal uptake being more sensitive to certain inhibitors. β-Alanine competitively inhibits only the low-affinity GABA uptake system in the glial cells. Correlation is observed between inhibition of GABA uptake by psychotropic drugs in glial cells and(More)
Binding of galactose-specific lectin PNA to the surface of erythrocyte membrane decreased by more than 90% in stressed rats. In the presence of sodium dodecyl sulfate, the lectin-binding fraction was electrophoretically separated into 3 major glycoprotein subfractions with molecular weights of 25, 37, and 50 kDa.
BACKGROUND Disorders of sex development (DSD) belong to uncommon pathologies; in addition, there are especially rare forms, such are ovotesticular disorders (OT), Turner syndrome and early malignisation of intraabdominal located gonads in the cases of androgen insensitivity syndrome. OBJECTIVE In this article we present four rare cases of DSD in female(More)
Actomyosine-like protein (AMLP) was isolated from the enriched glial fraction of the bovine brain cortex. The AMLP yield constitutes 0.05% of protein in the glial cells. The AMLP contained nucleotides; there were reversible association-dissociation reactions under the effect of Mg2+ ions and ATP characteristic of AMLP. ATP-ase of glial AMLP, activated with(More)
An enriched fraction of glial cells was isolated by centrifugation in a Ficollsucrose density gradient from bovine cerebral cortical tissue, and an actomyosinlike protein (AMLP) was obtained from it. The yield of the AMLP was 0.05% relative to glial cell protein. The AMLP was found to contain bound nucleotides and to give reversible association-dissociation(More)
Introduction Calcitonin gene-related peptide (CGRP) is one of the most potent vasodilator, which dilates multiple vascular beds, but the coronary circulation is particularly sensitive. The purpose of this study was to evaluate the influence of CGRP antagonist on: 1. Acute mortality; 2. Ventricular arrhythmias and; 3. Prostaglandin E2 (PGE2) production by(More)
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