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2013
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- A Heguy, Cosima Tatiana Baldari, Gianfranco Macchia, John L. Telford, Marialuisa Melli
- The Journal of biological chemistry
- 1992
The cytoplasmic domain of the human T cell-type interleukin-1 receptor (hIL-1R) is not involved in the binding, internalization, or nuclear localization of interleukin-1 (IL-1), but is essential for… (More)
- Franco Scalenghe, E. Turco, J. E. Edström, Vincenzo Pirrotta, Marialuisa Melli
- Chromosoma
- 1981
Fragments from section 3 of the salivary gland X chromosome of D. melanogaster were dissected with a micromanipulator. The DNA was extracted, cut and ligated to a λ vector in a volume of a few… (More)
- Franco Gabrielli, G Donadel, Giuliano Bensi, Adriana Heguy, Marialuisa Melli
- European journal of biochemistry
- 1995
We have described a protein (Hep27) [Donadel, G., Garzelli, C., Frank, R. & Gabrielli, F. (1991) Eur. J. Biochem. 195, 723-729] which is synthesized and accumulated in the nucleus of human… (More)
- Alessandra Brogi, Michelina Strazza, Marialuisa Melli, Elvira Costantino-Ceccarini
- Journal of cellular biochemistry
- 1997
The sphingomyelin pathway has been implicated in mediating the effect of several extracellular agents leading to important biochemical and cellular changes. The aim of this investigation is to study… (More)
- Massimo Riccio, Spartaco Santi, +6 authors Marialuisa Melli
- Neurobiology of Disease
- 2005
Cystatin B (cystB) is an anti-protease implicated in EPM1, a degenerative disease of the central nervous system. This work analyzes the pattern of expression of cystB in developing and adult… (More)
- Elena Cipollini, Massimo Riccio, +7 authors Marialuisa Melli
- Biochimica et biophysica acta
- 2008
Progressive myoclonus epilepsy type 1 (EPM1) is a neurodegenerative disease correlating with mutations of the cystatin B gene. Cystatin B is described as a monomeric protein with antiprotease… (More)
Nuclear localization of cystatin B, the cathepsin inhibitor implicated in myoclonus epilepsy (EPM1).
- Massimo Riccio, Rossella Di Giaimo, Simona Pianetti, Piernicola Palmieri, Marialuisa Melli, Spartaco Santi
- Experimental cell research
- 2001
Cystatin B is an anti-protease implicated in myoclonus epilepsy, a degenerative disease of the central nervous system. In vitro, cystatin B interacts with and inhibits proteases of the cathepsin… (More)
- Fabiana Falugi, Roberto Petracca, +13 authors Guido Grandi
- European journal of immunology
- 2001
The age-related and T cell-independent immunological properties of most capsular polysaccharides limit their use as vaccines, especially in children under 2 years of age. To overcome these… (More)
We have analyzed the upstream promoter of the human 7SK RNA gene to determine which protein factors are involved in the transcription of this gene by RNA polymerase III. Using a reconstituted in… (More)
- Serena Guida, Adriana Heguy, Marialuisa Melli
- Gene
- 1992
The evolutionary conservation of a sequence or part of it can help to identify the essential functional and structural domains within a protein. We have cloned and characterised a cDNA coding for the… (More)