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Alpha-synuclein, the major component of Lewy bodies, is thought to play a central role in the onset of synaptic dysfunctions in Parkinson's disease (PD). In particular, α-synuclein may affect dopaminergic neuron function as it interacts with a key protein modulating dopamine (DA) content at the synapse: the DA transporter (DAT). Indeed, recent evidence from(More)
Urban historical spaces are often characterized by a variety of shapes, geometries, volumes, materials. Their virtual reconstruction requires a critical approach in terms of acquired data's density, timing optimization, final product's quality and slimness. The research team has focused its attention on the study on Francesco Neglia square (previously named(More)
  • LA PREISTORIA, E LA PROTOSTORIA, DELLA SARDEGNA, ATTI DELLA XLIV, RIUNIONE SCIENTIFICA, ISTITUTO ITALIANO +32 others
  • 2013
SUMMARy-Multi-sensor digital acquisition of archaeological sites: the Montessu case study-Nowadays, 3D acquisition devices allow us to rapidly capture the geometry and color. State-of-the-art techniques, such as those developed at CRS4, are able to semi-automatically transform acquired data into 3D digital representations of Cultural Heritage artifacts(More)
A new approach free of time-consuming cloning procedures is described using MRF4 regulatory sequences acting as a physiological and muscular-specific promoter on human tissues; this method is useful for testing the expression of exogenous genes in cultured myoblasts and myotubes. pMRF4Z is a plasmid containing the regulatory sequences of Herculin (or MRF4,(More)
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