Learn More
BACKGROUND & AIMS Hepatic encephalopathy (HE) is a neurological complication observed in patients with liver disease and/or porto-systemic shunt. The proportion of cirrhotic patients developing overt HE is about 20%, and 60-80% of cirrhotic patients exhibit mild cognitive impairment potentially related to minimal HE. However, the pathophysiological(More)
OBJECTIVE Neurofilaments are leading neurochemical biomarkers for amyotrophic lateral sclerosis (ALS). Here, we investigated the effect of preanalytical factors on neurofilament concentrations in cerebrospinal fluid (CSF) in a "reverse" round-robin with 15 centers across Europe/U.S. METHODS Samples from ALS and control patients (5/5 each center, n = 150)(More)
In amyotrophic lateral sclerosis (ALS), bulbar dysfunction may lead to sialorrhea [1], which affects up to 25 % of patients [2], and is a significant purveyor of distress trough a permanent drooling mouth, an increased risk of saliva aspiration pneumonia and a limited tolerance of non-invasive ventilation (NIV). We recently demonstrated that radiotherapy(More)
Cerebral small vessel disease represents a heterogeneous group of disorders leading to stroke and cognitive impairment. While most small vessel diseases appear sporadic and related to age and hypertension, several early-onset monogenic forms have also been reported. However, only a minority of patients with familial small vessel disease carry mutations in(More)
Cerebrotendinous xanthomatosis (CTX) is among the few inherited neurometabolic disorders amenable to specific treatment. It is easily diagnosed using plasma cholestanol. We wished to delineate the natural history of the most common neurological and non-neurological symptoms in thirteen patients with CTX. Diarrhea almost always developed within the first(More)
We are grateful to Garuti and colleagues [1] for their insightful comments on our paper ‘‘Radiotherapy of salivary glands as treatment of sialorrhea in patients with amyotrophic lateral sclerosis requiring non-invasive ventilation.’’ All the issues highlighted by the authors are very relevant. Nevertheless, we would like to point out that the aim of this(More)
OBJECTIVE To investigate the indications and the outcomes of gastrostomy tube insertion in patients with parkinsonian syndromes. METHODS Consecutive patients with Parkinson's disease or atypical parkinsonism, seen in two French tertiary referral movement disorders centers, that received gastrostomy tube insertion (GTI) for feeding between 2008 and 2014(More)
Multiple sclerosis (MS) is a chronic disorder that affects the central nervous system myelin. However, a few radiological cases have documented an involvement of peripheral cranial nerves, within the subarachnoid space, in MS patients. We report the case of a 36-year-old female with a history of relapsing-remitting (RR) MS who consulted for a subacute(More)
  • 1