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BACKGROUND The overall aim of the GENESiS project is to identify quantitative trait loci (QTLs) for anxiety/depression, and to examine the interaction between these loci and psychosocial adversity. Here we present life-events data with the aim of clarifying: (i) the aetiology of life events as inferred from sibling correlations; (ii) the relationship(More)
There is considerable evidence for a unitary and dimensional view of the genetic vulnerability to symptoms of anxiety and depression. The GENESiS (Genetic Environmental-Nature of Emotional States in Siblings) Study aims to use a multivariate approach to detect genetic loci that contribute to individual differences in this vulnerability dimension. The study(More)
Lumbar punctures were performed on 69 patients who met Research Diagnostic Criteria (RDC) for major affective disorder, while they were drug-free and depressed. None of the patients met RDC for alcoholism. Cerebrospinal fluid 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) were measured by fluorometry and 3-methoxy-4-hydroxyphenylglycol(More)
Patients often experience 'preparatory-grief' as they cope with the dying process. Some may be depressed. The Terminally Ill Grief or Depression Scale (TIGDS), comprising grief and depression sub-scales, is a new self-report measure designed to differentiate between preparatory-grief and depression in adult inpatients. The initial 100-item inventory was(More)
A new test of manual dexterity and a test of spatial ability were administered to 37 participants of a microsurgery training course. Performance on microsurgical tasks undertaken by the trainees to assess their surgical skill correlated significantly (rho = -0.54, P < or = 0.01) with manual dexterity and (rho = 0.36, P < or = 0.05) spatial ability. The(More)
In this thesis, several novel techniques are proposed and demonstrated for measuring the coherent properties of materials and testing aspects of quantum information processing using a single crystal neutron interferometer. In particular we introduce methods for reciprocal space encoding of spatial information systematically in a neutron interferometer.(More)
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