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BACKGROUND The overall aim of the GENESiS project is to identify quantitative trait loci (QTLs) for anxiety/depression, and to examine the interaction between these loci and psychosocial adversity. Here we present life-events data with the aim of clarifying: (i) the aetiology of life events as inferred from sibling correlations; (ii) the relationship(More)
There is considerable evidence for a unitary and dimensional view of the genetic vulnerability to symptoms of anxiety and depression. The GENESiS (Genetic Environmental-Nature of Emotional States in Siblings) Study aims to use a multivariate approach to detect genetic loci that contribute to individual differences in this vulnerability dimension. The study(More)
Patients often experience 'preparatory-grief' as they cope with the dying process. Some may be depressed. The Terminally Ill Grief or Depression Scale (TIGDS), comprising grief and depression sub-scales, is a new self-report measure designed to differentiate between preparatory-grief and depression in adult inpatients. The initial 100-item inventory was(More)
Lumbar punctures were performed on 69 patients who met Research Diagnostic Criteria (RDC) for major affective disorder, while they were drug-free and depressed. None of the patients met RDC for alcoholism. Cerebrospinal fluid 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) were measured by fluorometry and 3-methoxy-4-hydroxyphenylglycol(More)
A new test of manual dexterity and a test of spatial ability were administered to 37 participants of a microsurgery training course. Performance on microsurgical tasks undertaken by the trainees to assess their surgical skill correlated significantly (rho = -0.54, P < or = 0.01) with manual dexterity and (rho = 0.36, P < or = 0.05) spatial ability. The(More)
In this thesis, several novel techniques are proposed and demonstrated for measuring the coherent properties of materials and testing aspects of quantum information processing using a single crystal neutron interferometer. In particular we introduce methods for reciprocal space encoding of spatial information systematically in a neutron interferometer.(More)
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