Maria Trulsson

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Ion channels and ion fluxes control many aspects of tissue homeostasis. During oncogenic transformation, critical ion channel functions may be perturbed but conserved tumor specific ion fluxes remain to be defined. Here we used the tumoricidal protein-lipid complex HAMLET as a probe to identify ion fluxes involved in tumor cell death. We show that HAMLET(More)
BACKGROUND Proteasomes control the level of endogenous unfolded proteins by degrading them in the proteolytic core. Insufficient degradation due to altered protein structure or proteasome inhibition may trigger cell death. This study examined the proteasome response to HAMLET, a partially unfolded protein-lipid complex, which is internalized by tumor cells(More)
Cell adhesion is tightly regulated by specific molecular interactions and detachment from the extracellular matrix modifies proliferation and survival. HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a protein-lipid complex with tumoricidal activity that also triggers tumor cell detachment in vitro and in vivo, suggesting that molecular(More)
HAMLET (Human a-lactalbumin made lethal to tumor cells) is a protein-lipid complex that kills tumor cells and immature cells but spares healthy, differentiated cells. The complex is formed from partially unfolded a-lactalbumin and oleic acid, both of which are abundant constituents of human milk. The folding change occurs after removal of Ca 2+ from native(More)
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