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Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits.
Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum
NF1 Is a Direct G Protein Effector Essential for Opioid Signaling to Ras in the Striatum
Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders
ELFN2 is a postsynaptic cell adhesion molecule with essential roles in controlling group III mGluRs in the brain and neuropsychiatric behavior
- Henry A. Dunn, S. Zucca, Maria T. Dao, C. Orlandi, K. Martemyanov
- BiologyMolecular Psychiatry
- 27 July 2019
It is concluded that extracellular transsynaptic scaffolding by ELFN2 in the brain is a cardinal organizational feature of group III mGluRs essential for their signaling properties and brain function.
Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits
Genetic behavioral screen identifies an orphan anti-opioid system
A conserved orphan receptor, GPR139, with anti-opioid activity is identified using forward genetics in Caenorhabditis elegans, demonstrating the potential of C. elegans as a scalable platform for genetic discovery of G protein–coupled receptor signaling principles.
The habenular G-protein–coupled receptor 151 regulates synaptic plasticity and nicotine intake
- B. Antolin-Fontes, Kun Li, I. Ibañez-Tallon
- Biology, ChemistryProceedings of the National Academy of Sciences
- 25 February 2020
GPR151 is identified as a critical modulator of habenular function that controls nicotine addiction vulnerability and suggests that small-molecule modulators of GPR151 may be useful for treatment of nicotine addiction.
The role of orphan receptor GPR139 in neuropsychiatric behavior
- Maria T. Dao, Hannah M. Stoveken, Yan Cao, K. Martemyanov
- Psychology, BiologyNeuropsychopharmacology
- 21 January 2021
It is shown that loss of GPR139 in mice results in delayed onset hyperactivity and prominent neuropsychiatric manifestations including elevated stereotypy, increased anxiety-related traits, delayed acquisition of operant responsiveness, disruption of cued fear conditioning and social interaction deficits, suggesting schizophrenia-like symptoms.