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Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits.
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Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum
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NF1 Is a Direct G Protein Effector Essential for Opioid Signaling to Ras in the Striatum
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Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders
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ELFN2 is a postsynaptic cell adhesion molecule with essential roles in controlling group III mGluRs in the brain and neuropsychiatric behavior
TLDR
It is concluded that extracellular transsynaptic scaffolding by ELFN2 in the brain is a cardinal organizational feature of group III mGluRs essential for their signaling properties and brain function.
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Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits
View on PubMed
Genetic behavioral screen identifies an orphan anti-opioid system
TLDR
A conserved orphan receptor, GPR139, with anti-opioid activity is identified using forward genetics in Caenorhabditis elegans, demonstrating the potential of C. elegans as a scalable platform for genetic discovery of G protein–coupled receptor signaling principles.
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The habenular G-protein–coupled receptor 151 regulates synaptic plasticity and nicotine intake
TLDR
GPR151 is identified as a critical modulator of habenular function that controls nicotine addiction vulnerability and suggests that small-molecule modulators of GPR151 may be useful for treatment of nicotine addiction.
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The role of orphan receptor GPR139 in neuropsychiatric behavior
TLDR
It is shown that loss of GPR139 in mice results in delayed onset hyperactivity and prominent neuropsychiatric manifestations including elevated stereotypy, increased anxiety-related traits, delayed acquisition of operant responsiveness, disruption of cued fear conditioning and social interaction deficits, suggesting schizophrenia-like symptoms.
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Allostatic Changes in the cAMP System Drive Opioid-Induced Adaptation in Striatal Dopamine Signaling
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