Maria T. Mendes

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Dendritic cells (DCs) are major immune components, and depending on how these cells are modulated, the protective host immune response changes drastically. Trypanosoma cruzi is a parasite with high genetic variability and modulates DCs by interfering with their capacity for antigen recognition, migration, and maturation. Despite recent efforts, the(More)
Traditional simulation methodology supports only changes in models state variables. Some models are better expressed by a combination of both changes in state variables and changes in structure. Dynamic Structure Discrete Event Specification (DSDEVS) is a recently introduced modelling and simulation formalism that provides full support for representing(More)
Triatomines are hematophagous arthropods that transmit Trypanosoma cruzi and Trypanosoma rangeli. Feeding behavior and pathogen transmission is known to vary between the different species, and this characteristic is directly or indirectly dependent on the bioactive molecules of the saliva that facilitate the vector-host-parasite interaction. Here, we(More)
Dendritic cells (DCs) are professional antigen-presenting cells with vital roles in the activation of host immunity. Ticks are bloodsucking arthropods that secrete bioactive compounds with immunomodulatory properties via their saliva. It is known that some tick species modulate the biology of DCs with different intensities; however, studies on Amblyomma(More)
Triatomines are blood-sucking vectors of Trypanosoma cruzi, the causative agent of Chagas disease. During feeding, triatomines surpass the skin host response through biomolecules present in their saliva. Dendritic cells (DCs) play a crucial role in the induction of the protection to aggressive agents, including blood-sucking arthropods. Here, we evaluated(More)
We appreciate the comments on the Letter to the Editor in the RSBMT regarding our study published in Rev Soc Bras Med Trop. 2017;50(1): 121-5. We also support and understand the importance of using the correct taxonomic status of each species, in this case, using Panstrongylus lignarius instead of P. herreri. However, it is important to mention that the(More)
INTRODUCTION Panstrongylus herreri is a main Chagas disease vector, and its success as a vector stems from its ability to establish domiciliated colonies; we aimed to explore its biology and reproduction. METHODS The average amount of blood ingested and the time from the beginning of a blood meal to the production of feces were recorded. RESULTS Females(More)
The data presented here were obtained from the saliva of three triatominae, Rhodnius prolixus, Triatoma lecticularia and Panstrongylus herreri from Montandon et al. study, doi:10.1016/j.ibmb.2016.02.009 [3]. These data were obtained from spectra generated by the mass spectrometry of proteins observed through the analysis of 2-D electrophoretic profiles. The(More)
Chagas disease is caused by the protozoan Trypanosoma cruzi and is characterized by cardiac, gastrointestinal, and nervous system disorders. Although much about the pathophysiological process of Chagas disease is already known, the influence of the parasite burden on the inflammatory process and disease progression remains uncertain. We used an acute(More)
BACKGROUND DATA Light emitting diode (LED) therapy has been proposed as an option for the treatment of many skin inflammatory processes. Dendritic cells (DCs) are important cells of skin that participate in the initiation and activation of skin immunity. The modulation of these cells by LED could explain much of its effects. OBJECTIVE Thus, the aim of(More)