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BACKGROUND Patients with chronic liver disease (CLD) and depression may be at a higher risk for various complications, including impaired quality of life and more advanced liver disease. The purpose of this study was to determine the prevalence of depression in CLD patients (non-alcoholic fatty liver disease (NAFLD), Hepatitis B (HBV), and Hepatitis C(More)
Traditionally, customer credit scoring aimed at distinguishing good payers from bad payers at the time of the loan application. However, the timing when customers become bad is also very interesting to investigate since it can provide the bank with the ability to compute the profitability over a customer's lifetime and perform profit scoring. The problem(More)
BACKGROUND Chronic hepatitis C virus (CH-C) infection is associated with metabolic conditions such as insulin resistance and type 2 diabetes (DM) and may increase the risk of cardiovascular diseases. AIM To assess the association of CH-C with risk factors for cardiovascular diseases using US population data. METHODS The National Health and Nutrition(More)
MOTIVATION The detection of transcription factor binding sites (TFBS) in genomic sequences is a basic task for elucidating the transcriptional aspects of gene regulation. Evaluation procedures applicable to the TFBS prediction outputs need improvement. Predicted TFBS located outside of the transcription associated areas are often neglected from the(More)
Recent studies of CH-C patients have demonstrated a strong association between IL28B CC genotype and sustained virologic response (SVR) after PEG-IFN/RBV treatment. We aimed to assess whether IL28B alleles rs12979860 genotype influences gene expression in response to PEG-IFN/RBV in CH-C patients. Clinical data and gene expression data were available for 56(More)
BACKGROUND An important step in understanding the conditions that specify gene expression is the recognition of gene regulatory elements. Due to high diversity of different types of transcription factors and their DNA binding preferences, it is a challenging problem to establish an accurate model for recognition of functional regulatory elements in(More)
The standard treatment for CH-C, pegylated interferon-α and ribavirin (PEG-IFN + RBV), is associated with depression. Recent studies have proposed a new role for cytokines in the pathogenesis of depression. We aimed to assess differential gene expression related to depression in CH-C patients treated with PEG-IFN + RBV. We included 67 CH-C patients being(More)
Low-temperature electron spin relaxation is studied by the optical orientation method in bulk n-GaAs with donor concentrations from 10 14 cm −3 to 5·10 17 cm −3. A peculiarity related to the metal-to-insulator transition (MIT) is observed in the dependence of the spin lifetime on doping near n D = 2·10 16 cm −3. In the metallic phase, spin relaxation is(More)