Maria Speranza Massei

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Posttransplant relapse is still the major cause of treatment failure in high-risk acute leukemia. Attempts to manipulate alloreactive T cells to spare normal cells while killing leukemic cells have been unsuccessful. In HLA-haploidentical transplantation, we reported that donor-derived T regulatory cells (Tregs), coinfused with conventional T cells (Tcons),(More)
Dear Editor, Acquired aplastic anemia (AA) is a bonemarrow (BM) failure syndrome, and it is defined by the concomitance of pancytopenia and an empty BM. Infections, cancers, and autoimmune diseases can lead to BM aplasia by mechanisms not completely understood. Differential diagnosis between AA and BM aplasia due to other conditions is difficult and can(More)
Because activating killer cell immunoglobulinlike receptors (KIRs) are heterogeneously expressed in the population, we investigated the role of donor activating KIRs in haploidentical hematopoietic transplants for acute leukemia. Transplants were grouped according to presence vs absence of KIR-ligand mismatches in the graft-vs-host direction (ie, of(More)
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