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  • Influence
Abuse potential and pharmacological comparison of tramadol and morphine.
The purpose of the study was to assess the abuse potential of the opioid analgesic tramadol. Tramadol (75, 150 and 300 mg), morphine (15 and 30 mg) and placebo were tested intramuscularly inExpand
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Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition.
Three of the predominant features of apoptosis are internucleosomal DNA fragmentation, plasma membrane bleb formation, and retraction of cell processes. We demonstrate that actin is a substrate forExpand
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Shift of the Cellular Oxidation‐Reduction Potential in Neural Cells Expressing Bcl‐2
Abstract: Expression of the protooncogene bcl‐2 inhibits both apoptotic and in some cases necrotic cell death in many cell types, including neural cells, and in response to a wide variety ofExpand
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Activation of CPP32 during apoptosis of neurons and astrocytes
Members of the interleukin‐1β‐converting enzyme (ICE)/CED‐3 protease family have been implicated in apoptosis in both vertebrates and invertebrates. Using primary culture methods, we report thatExpand
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Phosphorylation of the common neurotrophin receptor p75 by p38beta2 kinase affects NF-kappaB and AP-1 activities.
The signaling pathways invoked by ligand binding to the common neurotrophin receptor p75NTR are incompletely understood. Using the yeast two-hybrid system, we identified the mitogen-activated proteinExpand
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Abuse liability of testosterone
Anabolic-androgenic steroids (AAS) are used by athletes to enhance performance and physique. Case reports and observations propose that AAS have mood elevating properties and that chronic use leadsExpand
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Psychoactivity and abuse potential of sumatriptan
Sumatriptan is a 5‐HT1Dagonist of therapeutic use in migraine and cluster headaches. To determine the profile of psychoactivity and abuse potential, a double‐blind Latin‐square crossover study wasExpand
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Screening assay for oxidative stress in a feline astrocyte cell line, G355-5.
An often-suggested mechanism of virus induced neuronal damage is oxidative stress. Astrocytes have an important role in controlling oxidative stress of the Central Nervous System (CNS). AstrocytesExpand
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P-NMR Spectroscopy of Roots of Intact Corn Seedlings.
The application of (31)P nuclear magnetic resonance spectroscopy to the study of metabolism in roots of intact corn seedlings is described. (31)P-NMR spectra of developmentally distinct parts ofExpand
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Psychopharmacology and abuse potential of transnasal butorphanol.
The effects of butorphanol administered by a nasal spray (transnasal, TN) and by intramuscular (IM) injection were compared to determine the onset of action, relative potency, profile of effects, andExpand
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